Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Pulmonology
Volume 2014, Article ID 368780, 4 pages
http://dx.doi.org/10.1155/2014/368780
Case Report

Improvement with Infliximab of a Disseminated Sarcoidosis in a Patient with Crohn’s Disease

1Hospices Civils de Lyon, 69003 Lyon, France
2Université de Lyon, 69007 Lyon, France
3Université Lyon1, 69007 Lyon, France
4INRA, UMR754, 69007 Lyon, France

Received 24 November 2013; Accepted 31 December 2013; Published 6 February 2014

Academic Editors: E. Fernández Pérez, S. Ohshimo, T. Peros-Golubicic, and C. van Moorsel

Copyright © 2014 Nader Chebib et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sarcoidosis and Crohn’s disease are systemic granulomatous disorders affecting the lung and the intestine, respectively, with variable involvement of other organs and are seldom associated. While anti-TNFα is a recognized treatment of Crohn’s disease, its usage is discussed in sarcoidosis. A 42-year-old man presented with an 11-year-long history of Crohn’s disease; upon discovery of an abnormal chest CT scan the diagnosis of multivisceral sarcoidosis was made and, later, a treatment with an anti-TNFα agent, infliximab, was started, because of worsening Crohn’s disease recurrences. CT scan demonstrated net regression of pulmonary opacities and hepatosplenic lesions. Pathologies obtained from the intestinal tract and the bronchi of the patient were, respectively, characteristic of Crohn’s disease and sarcoidosis leading to the diagnosis of both diseases. We report a rare case of steroid resistant Crohn’s disease associated with multivisceral sarcoidosis, treated successfully by an anti-TNFα agent, infliximab.