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Case Reports in Pulmonology
Volume 2015, Article ID 358926, 6 pages
http://dx.doi.org/10.1155/2015/358926
Case Report

A Case of Disseminated Cryptococcal Infection and Concurrent Lung Tuberculosis in a Patient under Steroid Therapy for Interstitial Pneumonia

1Division of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Japan
2Division of Pulmonary Medicine, Department of Internal Medicine, Kawasaki Municipal Hospital, Japan
3Department of Pathology, Keio University School of Medicine, Japan
4Center for Infectious Diseases and Infection Control, Keio University School of Medicine, Japan

Received 18 March 2015; Accepted 25 May 2015

Academic Editor: Tun-Chieh Chen

Copyright © 2015 Aoi Kuroda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Both disseminated cryptococcal infection and tuberculosis occur in hosts with impaired cell-mediated immunity, but there have been few reports about the concurrent infections in patients without human immunodeficiency virus infection. A 64-year-old man, who had been taking corticosteroids for interstitial pneumonia, was diagnosed with disseminated cryptococcal infection. While the patient was receiving anticryptococcal therapy, pulmonary tuberculosis also emerged. The patient developed acute exacerbation of interstitial pneumonia and passed away. Based on the patient’s clinical course, serial computed tomography images, and autopsy results, we believe that the preceding several months of corticosteroid treatment might have contributed to these coinfections in the lungs already vulnerable due to underlying fibrosis.