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Case Reports in Pulmonology
Volume 2015, Article ID 361694, 3 pages
http://dx.doi.org/10.1155/2015/361694
Case Report

Interstitial Lung Disease in Werner Syndrome: A Case Report of a 55-Year-Old Male Patient

1Service de Pneumologie, Hôpital Universitaire Tenon, 75020 Paris, France
2Service de Dermatologie, Hôpital Universitaire Cochin, 75014 Paris, France
3Service de Dermatologie, Hôpital Universitaire Tenon, 75020 Paris, France

Received 3 September 2015; Accepted 12 November 2015

Academic Editor: Michael Kreuter

Copyright © 2015 Tiphaine Goletto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Werner syndrome (WS) is a progeroid or premature aging syndrome characterized by early onset of age-related pathologies and cancer. The average life expectancy of affected people is 52.8 years and tends to increase. The major causes of death are malignancy and myocardial infarction. Increased telomere attrition and decay are thought to play a causative role in the clinical and pathological manifestations of the disease. Although telomere length, with or without germline mutation, is known to be associated with interstitial lung disease, the latter is not associated with WS. To the best of our knowledge, we report the first case describing a WS patient with fatal ILD. This case suggests that older patients with WS could develop ILD. Clinical outcome of WS patients may thus be improved by counselling them regarding smoking cessation or other exposure and by proposing antifibrotic therapy.