Case Report
Primary Pulmonary Malignant Melanoma Found While Evaluating New Onset Cough: A Case Presentation and Literature Review
| SPECIMEN (S): OTHER, SURGICAL BIOPSY, RIGHT LOWER LOBE LUNG MASS | | DIAGNOSIS: | | ALERTALERTALERT | | LUNG, RIGHT LOWER LOBE CORE BIOPSY | | --- INVASIVE POORLY DIFFERENTIATED MALIGNANT NEOPLASM (SEE COMENT) | | COMMENT: | | The sections show lung parenchyma which is infiltrated by a very | | poorly differentiated malignant neoplasm composed of single cells | | and small infiltrative nests with large, hyperchromatic nuclei | | and scant cytoplasm. The background milieu consists of fibrosis, | | hemosiderin-laden macrophages and a dense lymphoid infiltrate. | | The tumor cells are positive for S100 and SOX-10. The primary | | diagnostic differential for this pattern of staining is melanoma. | | IMMUNOHISTOCHEMISTRY AND IMMUNOFLUORESCENCE RESULTS | | S100: Positive ----- SOX-10 Positive | | HMB45: Very Focal Positive ----- MART-1: Very focal positive | | MITF: Very Focal Positive | | AE13: Negative ----- Polytypic Keratin: Negative | | CK20: Negative ----- CDX2: Negative |
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