Case Reports in Radiology / 2014 / Article / Tab 2

Case Report

Magnetic Resonance Imaging in Marchiafava-Bignami Syndrome: A Cornerstone in Diagnosis and Prognosis

Table 2

Correlation of imaging findings in MBS with pathophysiology [1, 6].

MRI findingsUnderlying pathophysiology

1Hyperintensity on T2 weighted imagesEdema and myelin damage
2Hypointensity on T1 weighted imagesTotal loss of myelin with replacement of the region by a cyst
3Hyperintense rims and hypointense cores on FLAIR images Damage to the myelin at the rim with a central necrotic area
4Uniformly hyperintense lesions on FLAIR Mixture of demyelination and edema
5Areas of restricted diffusion on DWI (acute phase)Cytotoxic edema