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Case Reports in Radiology
Volume 2015, Article ID 730719, 6 pages
Case Report

Progressive Diffuse Osteonecrosis in a Patient with Secondary Hemophagocytic Lymphohistiocytosis

Department of Radiology, University of Minnesota Medical Center, Minneapolis, MN, USA

Received 15 August 2015; Revised 7 October 2015; Accepted 27 October 2015

Academic Editor: Salah D. Qanadli

Copyright © 2015 Takashi Takahashi and Jeffrey Rykken. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This is a case report with serial imaging showing progression of diffuse osteonecrosis in a patient after a diagnosis of secondary hemophagocytic lymphohistiocytosis (HLH). While bone marrow involvement in HLH has been long noted at histological evaluation and is itself one of the diagnosis criteria, to the best of our knowledge, there has been no previous publication addressing osseous image findings in a patient with HLH.