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Case Reports in Radiology
Volume 2017, Article ID 5972940, 14 pages
Case Report

New Insights about Pulmonary Epithelioid Hemangioendothelioma: Review of the Literature and Two Case Reports

1Department of Radiology, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal
2Department of Radiology, Hospital Povisa, Vigo, Spain
3Department of Pathology, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
4Department of Pathology, Hospital Povisa, Vigo, Spain

Correspondence should be addressed to Romeu Duarte Mesquita; moc.liamg@atiuqsem.uemor

Received 10 April 2017; Accepted 4 July 2017; Published 14 August 2017

Academic Editor: Suayib Yalcin

Copyright © 2017 Romeu Duarte Mesquita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pulmonary epithelioid hemangioendothelioma (PEH) is a rare neoplasm of vascular origin. There are three different major imaging patterns identified in thoracic manifestation of epithelioid hemangioendothelioma: (1) multiple pulmonary nodules; (2) multiple pulmonary reticulonodular opacities; and (3) diffuse infiltrative pleural thickening. Radiographically, presence of bilateral multiple nodules is the most common pattern of presentation. The diagnosis is made on the basis of histopathological findings and confirmed by positive immunohistochemistry staining. Although the prognostic factors for PEH have not yet been well established, a better prognosis is usually associated with the multinodular pattern. We report two different imagological presentations of this rare disease, based on two institutional experiences, along with a review of the relevant literature.