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Case Reports in Radiology
Volume 2017, Article ID 9159035, 9 pages
Case Report

Extraosseous Multiple Myeloma: Case Report of Presentation in the Lower Extremity Soft Tissues with Literature Review

1Department of Radiology, University of Minnesota, Minneapolis, MN, USA
2Musculoskeletal Division, Department of Radiology, University of Minnesota, Minneapolis, MN, USA

Correspondence should be addressed to Takashi Takahashi; ude.nmu@500sakat

Received 20 August 2017; Revised 7 November 2017; Accepted 20 November 2017; Published 17 December 2017

Academic Editor: Roberto Iezzi

Copyright © 2017 Jeff Ames et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A rare presentation of extramedullary multiple myeloma in the soft tissues of the bilateral thighs prompted a literature review of published cases of extramedullary multiple myeloma (EM-MM) and solitary plasmacytomas to determine the relative anatomic distribution of these lesions. All available published cases in English were included in the analysis, dating back to 1966 and including 2,538 extramedullary myeloma or solitary plasmacytoma lesions. Analysis of the anatomic location of EM-MM lesions demonstrates the majority being in the upper airway (33.8%), soft tissues including retroperitoneum and abdomen (14.1%), gastrointestinal tract (10.3%), central nervous system, head and neck (16.0%), and GU (2.4%). We were able to find only 44 documented cases of extremity soft tissue lesions, comprising 1.7% of all lesions.