The Diagnostic Challenge of an Infrequent Spectrum of Cryptococcus Infection

Figure 6

Microscopy slides: (A) Hematoxylin and eosin staining (H & E) observing spherical to oval yeasts with size variability. (B) Granulomas with peripheral fibrosis showing the chronicity of the process. (C) Larger increase in the center of the granuloma by identifying numerous yeasts with thick capsules of mucopolysaccharide giving the characteristic appearance of having a free space around them. (D) FNA of supraclavicular lymph node showing multiple spherical yeast structures. (E) Grocott-methenamine silver (GMS) positive staining highlighting the wall of the fungus. (F) Positive mucicarmine staining by radiating the fungus capsule.