A Case Series of Breast Metastases from Different Extramammary Malignancies and Their Literature Review

Figure 2

Case 2. A 60-year-old woman diagnosed with papillary serous ovarian carcinoma. A palpable mass in the left breast was noticed by the patient 2 years after initial diagnosis. Mammogram revealed dermal thickening and diffusely increased breast density (a–b). A distortion was evident in the breast tail as well, indicating skin retraction (b). Grayscale and Doppler ultrasound showed bilateral hypoechoic irregular masses with angular margins. A nonparallel orientation and central vascularity were observed in some masses. Multifocal and diffuse distribution of the lesions was noted on ultrasound (c–g). Similarly, subtracted images from magnetic resonance demonstrated multiple irregular masses with circumscribed margins and rim enhancement (h). Conglomerate lesions infiltrating the major pectoralis muscle were also exposed (i). HE staining and immunohistochemistry analysis of the metastases. HE staining revealed the malignant cells in the breast tumor (j), and the immunohistochemistry analysis indicated that the cells were positive for PAX8 (k) and CA125 (l).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)