A Case Series of Breast Metastases from Different Extramammary Malignancies and Their Literature Review

Figure 5

Case 5. A 45-year-old woman with metastatic melanoma that presented as an isolated breast tumor. Upon interrogation, the patient reported a 1-month history of migraine and attacks of vertigo. Magnetic resonance imaging showed multiple heterogeneous enhancing masses suggesting the presence of metastatic disease (a). Intracranial hemorrhage focus was corroborated by fluid–fluid levels on gradient-echo imaging (b). Following the suspicion of metastatic disease, mammography was performed, demonstrating a subtle increase in density in both breasts (c–d). On ultrasound, an oval, hypoechoic mass with multilobulated margins was shown in the left breast (e). HE staining and immunohistochemistry analysis of the metastases. HE staining revealed the malignant cells in the breast tumor (f), and the immunohistochemistry analysis indicated that the cells were positive for melan-A (g).

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