Malignant Intracerebral Nerve Sheath Tumors: A Case Report with Review of the Literature

Table 1

Clinical findings and outcomes in 15 previously reported cases of MINST.

Authors [reference]	Age (years)/ sex	Location	Special aspect	Clinical presentation (duration if reported)	Treatment	Recurrence; (months)	Follow-up (months)	Survival (at last F/U)
Ellis et al., 2011 [7]	9/F	Right fronto-temporal	NF-1	Headaches (2 months)	STR + chemo + RT	No	6	Alive
Barnard et al., 2011 [9]	75/F	Left frontal lobe	—	Personality changes, aphasia, gait instability, and confusion	GTR + RT	No	12	Alive
Oztanir et al.,2009 [10]	1/F	Right fronto-temproparietal	NF-1	Developmental delay, vomiting, and lethargy	STR	NA	1.5	Death at 6 weeks due to sepsis
Kozić et al., 2008 [11]	39/M	Left intrapontine	—	Left facial paresthesia, ataxia, and dysarthria (12 months)	Biopsy	NR	NR	NR
De Cauwer et al., 2007 [5]	68/F	Left parieto-frontal (rolandic area)	NF-1; TV	Syncope, dyssthesia of left arm, and seizure	GTR + RT	5	5	Dead
Beauchesne et al., 2004 [2]	35/M	Right cerebral peduncle	—	Horizontal dipoplia, left hearing loss, headache, nausea, and ataxia (2 months)	Biopsy + RT + chemo	17	29	Dead
Maiuri et al., 2004 [12]	36/M	Cerebellar vermis	—	Headache, vomiting, dizziness, vision loss, and ataxia (2 months)	GTR + RT	6	8	Dead
Bornstein-Quevedo et al., 2003 [4]	3/M	Right parieto-occipital	TV	Frontal headache, vomiting, irritability, and aggressive behavior (2 months)	STR	NA	0.33	Died at 10 days due to ICH
Takahashi et al., 2000 [6]	57/M	Left lateral ventricle	NF-1	Memory disturbance, disorientation	GTR + RT + Chemo	No	4	Dead
Tanaka et al., 2000 [13]	4/F	Right parieto-occipital	—	Headache, vomiting	GTR	No	19	Alive
Sharma et al., 1998 [14]	8/F	Right temporal	—	Seizures	GTR	No	17	Alive
Jung et al., 1995 [15]	40/M	Right lateral ventricle	—	Headache, vomiting, and drowsiness	GTR + RT	8	8	Dead
Singh et al., 1993 [16]	61/F	Right cerebellar	—	Headache, vomiting, unsteady gait, and diplopia	GTR + RT	10	18	Dead
Stefanko et al., 1986 [17]	15/M	Left parieto-occipital	—	Headache, vomiting	GTR + RT + Chemo	5 and 8	9	Dead
Bruner et al., 1984 [18]	18/M	Frontal lobe	—	Syncope	GTR	24, 48, and 66	66	Alive
Present case	18/M	Right fronto-parietal	NF-1	Left side numbness, severe headache, pain in left upper extremity, and ICH	GTR, RT	44	52	Dead

GTR: gross-total resection; STR: subtotal resection; RT: radiation therapy; chemo: chemotherapy; ICH: intracerebral hemorrhage; NA: not applicable; NR: not reported; NF-1: neurofibromatosis type 1; TV: triton variant.