Spontaneous Involution of a Presumably Rathke’s Cleft Cyst in a Patient with Slight Subclinical Hypopituitarism: A Case Report and Review of the Literature

Table 1

Reported cases of spontaneous regression of RCC.

Case number	Authors and year	Age (yrs), sex	Symptoms	Time to regression (mos)	Endocrine evaluation
1	J. D. Simmons and L. A. Simmons, 1999 [15]	15, F	Amenorrhea	3	Low LH, FSH, and estradiol
2	Igarashi et al., 1999 [13]	25, F	Visual field defect	NA	NA
		46, M	Visual field defect	NA	NA
		34, M	Visual field defect	NA	NA
		58, F	Visual field defect	NA	NA
3	Saeki et al., 1999 [17]	59, F	Visual field defect	1	Normal
		30, M	Visual field defect	0.5	Low LH, FSH, and GH
4	Terao et al., 2001 [18]	67, M	Visual field defect	60	NA
5	Nishio et al., 2001 [14]	14, M	Headache	3	Normal
		31, F	Headache	6	Normal
6	Nishioka et al., 2006 [10]	NA	NA	NA	Hypopituitarism
		NA	Visual field defect	NA	NA
7	Maruyama et al., 2008 [19]	81, M	Headache	0.5	Hypopituitarism
8	Amhaz et al., 2010 [3]	57, M	Headache	5	Low testosterone
		32, F	Headache	44	Normal
		29, F	None	31	Normal
		18, F	Headache	7	Elevated ACTH
		17, F	Headache	21	Normal
		14, M	Headache	11	GH slightly high
		6, M	Headache	41	Normal
		5, M	Growth	100	Low testosterone and TSH
		29, F	deceleration; Headache	18	Normal
9	Maniec and Watson, 2011 [5]	59, M	Headache	6	NA
10	Munich and Leonardo, 2012 [7]	8.5, F	Growth deceleration	12	Low GH, central hypothyroidism

NA, information not available in paper; M, male; F, Female; mons, months; yrs, years; ACTH, adrenocorticotropic hormone; TSH, thyroid-stimulating hormone; T3, triiodothyronine; T4, thyroxine; GH, growth hormone; LH, luteinizing hormone; FSH, follicle-stimulation hormone.