Blowhole Colostomy for Clostridium difficile-Associated Toxic Megacolon

Table 1

Antibiotic usage.

Time point	Antibiotic (posology)	Comments
Laparoscopic sigmoidectomy; POD0	Amoxicillin-clavulanic acid (1 × 1 gram IV); Amoxicillin-clavulanic acid (1 × 1 gram IV)	Peroperatively
POD1	Amoxicillin-clavulanic acid (4 × 1 gram IV)
POD2	Amoxicillin-clavulanic acid (2 × 1 gram IV)
POD3	None
Blowhole colostomy	Piperacillin-tazobactam (1 × 4 grams IV); Metronidazole (1 × 500 milligrams IV)	Peroperatively
POD1	Piperacillin-tazobactam (4 × 4 grams IV); Metronidazole (3 × 500 milligrams IV)
POD2	Piperacillin-tazobactam (3 × 4 grams IV); Metronidazole (3 × 500 milligrams IV); Tigecycline (1 × 100 milligrams IV)
POD3-POD4	Tigecycline (1 × 100 milligrams IV); Metronidazole (3 × 500 milligrams IV)
POD5–POD7	Metronidazole (3 × 500 milligrams IV)
POD8–POD14	Metronidazole (3 × 500 milligrams PO)	Discharged on POD12; Stop antibiotics on POD14

IV: intravenous; PO: per os; POD: postoperative day. Postoperative days after the second procedure are marked with an asterisk.