Breast Metastasis in Esophagus Cancer: Literature Review and Report on a Case

Table 1

Breast metastasis from esophagus cancer—cases characteristics.

Case	Study	Patient sex and age	Tumor location	Tumor pathology	Esophageal cancer treatment	The breast metastasis	Interval between tumor and metastasis	Metastasis management and outcome
1	Nielsen et al., 1981 [2].	84 y/o female	Middle esophagus	Squamous cell carcinoma	No management available	5 cm central mass located in the right breast	Three months after diagnosis	Breast metastasis detected at autopsy
2	Miyoshi et al., 1999 [3].	44 y/o male	Upper middle esophagus	Squamous cell carcinoma	Radiotherapy due to metastasis	Painful mobile hard mass beneath the left nipple	Two months after diagnosis	The patient died 2 months later; Autopsy: lung, liver, diaphragm, peritoneum, and spine metastasis
3	Shiraishi et al., 2001 [4].	57 y/o female	Middle esophagus	Squamous cell carcinoma	Esophagectomy Radiotherapy	2.5 cm × 2.6 cm mobile painless hard mass in the upper outer quadrant of the left breast	Two years after surgery	The patient had modified radical mastectomy; she was alive 6 months later
4	Santeufemia et al., 2006 [5].	51 y/o male	Middle esophagus	Squamous cell carcinoma	Esophagectomy Chemotherapy	3 cm × 3 cm hard mobile nodule in the upper lateral quadrant of the left breast	Four months after surgery	Surgical resection of breast and brain relapse. Successful outcome 11 years later
5	Norooz et al., 2009 [6].	35 y/o female	Middle lower esophagus	Squamous cell carcinoma	Esophagectomy Chemotherapy Radiotherapy	4 cm × 4.5 cm mobile, painful, hard mass just below the right nipple	Metastatic breast lesion was the first sign of the esophagus cancer	Resection of the breast mass; The patient has acceptable health condition 6 months after the treatment with no sign of recurrence
6	Jena et al., 2014 [7].	32 y/o male	Lower esophagus	Adenocarcinoma	Esophagogastrectomy Chemotherapy	2 cm × 2 cm mobile hard lump in the upper outer quadrant of left breast	Two years after surgery	No management available; the patient died later
7	Our study 2016	57 y/o female	Middle lower esophagus	Squamous cell carcinoma	No management available	10 cm × 9.5 cm painful hard mass involving the left breast	One year after diagnosis	The patient died 2 months later