Demanding Diagnosis of Splenic Angiosarcoma as Cause of Delayed Treatment of Spontaneous Splenic Rupture: A Case Report and Literature Review

Table 1

Review of literature.

Reference	Age	Clinical manifestations	Laboratory results	Radiologic Findings	Mean of diagnosis	Metastases at surgery	Treatment	Prognosis
Liu et al. 2012 [5]	33	Pain	NA	Splenic rupture	CT	Yes	Emergency splenectomy + CT	NA
Duan et al. 2013 [2]	65	Pain	Anemia	Splenic rupture	CT	Liver metastases	Emergency splenectomy	NA
Hamid et al. 2010 [6]	70	Dyspnea	Anemia	Left pleural effusion	CT	No	Elective splenectomy	AWD, 8 months
Oztürk et al. 2007 [7]	49	Pain	Anemia, thrombocytopenia	Nodular spleen, splenomegaly	CT, MRI	No	Elective splenectomy + CT	DOD, 7 months
Raffel et al. 2010 [8]	64	Fatigue	Thrombocytopenia	Nodular spleen, lytic bone lesions	CT biopsy (BOM neg)	Bone metastases	Elective splenectomy + CT	DOD, 4 months
Takeuchi et al. 2010 [9]	37	Pain	NA	splenomegaly	CT	No	Elective splenectomy	DOD, 24 months
Hara et al. 2010 [10]	48	Fatigue	Thrombocytopenia	Splenomegaly, hepatomegaly	CT, MRI, FDG-PET biopsy (BOM neg)	No	Elective splenectomy + CT	DOD, 72 months
Kranzfelder et al. 2012 [11]	62	Pain	NA	Splenic rupture, liver nodules	CT	Liver metastases	Emergency splenectomy + CT	DOD, 8 months

NA: not addressed; CT: computerized tomography; CHT: chemotherapy; DOD: date of death after diagnosis; MRI: magnetic resonance imaging; BOM: bone marrow biopsy.