Interesting Case of Skin Metastasis in Colorectal Cancer and Review of Literature

Table 1

Cases of rectal cancer with cutaneous metastasis.

Author, year	Age (years)	Sex	Histology	Stage	Primary cancer treatment	Interval (months)	Skin metastasis location	Skin metastasis morphology	Skin metastasis treatment	Survival (follow-up time in months)
Gottlieb and Schermer, 1970 [12]	72	F	Adenocarcinoma-sigmoid	NA	Sigmoidectomy	57	Palms	Nodules	—	NA
Gottlieb and Schermer, 1970 [12]	67	M	Adenocarcinoma-descending colon	NA	Left hemicolectomy	4	Face	Nodules/ulcers	NA	6 months
Gray and Das, 1989 [13]	79	F	Adenocarcinoma	—	Radiation	0	Leg	Nodules	None	No (18)
Reed and Stoddard, 1992 [14]	68	F	Adenocarcinoma, poorly differentiated	—	LAR	4	Perineum	Nodules	APR	—
De Friend et al., 1992 [15]	49	F	Adenocarcinoma	III	LAR	7	Perineum	Nodules	WLE	—
Kauffman and Sina, 1997 [5]	50	M	Adenocarcinoma, signet ring	IV	LAR+ACR	36	Multiple	Plaques	None	No (3)
Stavrianos et al., 2000 [16]	78	M	Adenocarcinoma-well differentiated	III	Transverse colon resection	3	Cheek oral commissure	Ulcers	RT followed by full thickness excision	11
Sukumar and Qureshi, 2001 [17]	75	M	Adenocarcinoma, poorly differentiated		APR+RT	3	Penile skin	Nodule, ulcers	NA	2
Adani et al., 2001 [18]	70	F	Adenocarcinoma	III	APR+AC	36	Leg	Nodules	CR	Yes (14)
Tsai et al., 2002 [19]	47	M	Adenocarcinoma, signet ring	III	APR+AC	11	Multiple	Nodules	C	No (4)
Melis et al., 2002 [20]	41	M	Adenocarcinoma	IV	NCR	1	Perineum	Plaques	None	—
Damin et al., 2003 [21]	44	M	Adenocarcinoma	II	LAR	6	Groin	Zosteriform	R	No (5)
Hayashi et al., 2003 [22]	50	M	Adenocarcinoma, mucinous	—	LAR	4	Perineum	Nodules	None	—
Wright et al., 2003 [23]	81	F		IV			Cholecystectomy scar			NA
Sarid et al., 2004 [24]	60	F	Adenocarcinoma, mucinous	III	NR+LAR+ACR	16	Chest, abdomen	Ulcers	WLE	No (56)
Alexandrescu et al., 2005 [25]	62	F	Adenocarcinoma	—	NA	60	Scar site	Masses	—	—
Alexandrescu et al., 2005 [25]	46	M	Adenocarcinoma	—	NA	36	Scar site	Masses	—	—
Reuter et al., 2007 [26]	69	M	Adenocarcinoma	II	APR+ACR	5	Perineum	Plaques	None	No (6)
Tan et al., 2006 [27]	70	M	Adenocarcinoma, mucinous	IIIB	LAR+AC	20	Back	Nodules	WLE, C	—
Tan et al., 2006 [27]	51	F	Adenocarcinoma	IIIB	APR	10	Perineum	Nodules	WLE, CR	9 months
Kilickap et al., 2006 [28]	29	M	Adenocarcinoma, signet ring	IIIA	LAR+APR+ACR	14	Chest wall, axilla	Nodules	WLE+C	Yes (4)
Fyrmpas et al., 2006 [29]	62	M	Adenocarcinoma-moderately differentiated	NA	Right hemicolectomy	36	Chin	Nodules	Excision biopsy	8 months
Nasti et al., 2007 [30]	76	F	Adeno carcinoma	III	Preop CRT	0	Face with parotid gland involvement	NA	NA	15
Gazoni et al., 2008 [31]	55	F	Adenocarcinoma, poorly differentiated	IV	Colostomy+CR	0	Perineum	—	CR	No (3)
Gazoni et al., 2008 [31]	66	M	Adenocarcinoma, poorly differentiated	IV	Colostomy+CR	0	Perineum	—	CR	No (4)
Gazoni et al., 2008 [31]	68	M	Adenocarcinoma, poorly differentiated	IV	Colostomy+CR	0	Thigh, axilla	—	CR	No (3)
Gazoni et al., 2008 [31]	72	M	Adenocarcinoma	IV	Colostomy+CR	0	Perineum	—	CR	No (5)
Gazoni et al., 2008 [31]	65	M	Adenocarcinoma	IV	Colostomy+CR	0	Perineum	—	CR	No (7)
Gazoni et al., 2008 [31]	78	M	Adenocarcinoma	IV	Stent+CR	0	Perineum	—	CR	No (1)
McWeeney et al., 2009 [32]	72	M	Adenocarcinoma	III	Ileostomy+NCR	6	Perineum	Nodules	WLE	—
Kurihara and Watanabe, 2009 [33]	66	M		III			Right thigh			7 months
Ayadi, 2009 [34]	63	M	Small cell carcinoma-rectum	III	CT	5	Scalp	Ulceroproliferative mass	Palliative CT	16 months
Saladzinskas et al., 2010 [35]	64	M	Adenocarcinoma, mucinous	IIA	NR+LAR	42	Face	Ulcers	WLE	Yes (7)
Ismaili et al., 2011 [36]	50	F	Adenocarcinoma, signet ring	IV	None	0	Multiple	Zosteriform	None	No (1)
Horiuchi et al., 2011 [37]	53	M	Adenocarcinoma	II		36	Scalp			6 months
Civitelli et al., 2011 [38]	73	F	Adenocarcinoma	III		Few days	Abdominal wall, chest, back			6 months
Balta et al., 2012 [39]	46	M	Adenocarcinoma, mucinous	IIIB	Colostomy	12	Perineum	Ulcers	None	—
Wang et al., 2012 [40]	63	M	Adenocarcinoma	III		6	Chest, neck, upper limb			2 weeks
Nasrolahi, 2013 [10]	33	M	Adenocarcinoma	IV	CT	3	Chest, back, neck	Plaque	CT	Few weeks
Rajan et al., 2012 [41]	36	M	Adenocarcinoma	IV		24	Lower extremities			3 months
Hamid and Hanbala, 2012 [42]	70	NA	Adenocarcinoma	II		86	Scalp, upper trunk			NA
Russo et al., 2012 [43]	72	M	Adenocarcinoma-signet cells	II	Right hemicolectomy	33	Back	Nodules	WLE	Yes
Rashid et al., 2012 [44]	65	M	Adenocarcinoma	III	Right hemicolectomy	0	Forearm	Nodules	—	17 months
de Miguel Valencia et al., 2013 [45]	55	M	Adenocarcinoma, mucinous	IIIB	NCR+APR+AC	18	Multiple	Nodules	None	No (—)
Ozgen et al., 2013 [46]	65	M	Adenocarcinoma	IIA	NCR+LAR+ACR	18	Perineum	Nodules	CR	Yes (12)
Akpak et al., 2014 [47]	47	F	Adenocarcinoma	IV	APR	36	Perineum	Ulcers	WLE+CR	—
Nesseris et al., 2013 [7]	80	M	Adenocarcinoma	III	Right hemicolectomy	12 m	Lower abdomen	Ulceroproliferative growth	2 cycles of CT	Yes
Kushwaha et al., 2013 [48]	40	M	Adenocarcinoma-signet cells	IV	CT	0	Chest, neck	Nodules	CT	4 months
Kushwaha et al., 2013 [48]	56	M	Adenocarcinoma	II	APR+CT	10	Chest, neck	Nodules	NA	8 months
Kushwaha et al., 2013 [48]	43	F	Adenocarcinoma	II	LAR+CT	8	Chest	Nodules	NA	7 months
Rogers et al., 2014 [49]	50	M	Adenocarcinoma, mucinous	IV		72	Scalp	Nodules	WLE	NA
Rogers et al., 2014 [49]	45	F	Adenocarcinoma		NCR+SX+ACR		Scalp	Nodules	WLE	Yes
Dehal et al., 2016 [50]	47	M	Adenocarcinoma, mucinous	IV	CR	1	Perineum	Nodules	R	Yes (12)
Fragulidis et al., 2015 [51]	62	M	Adenocarcinoma	IV	Endoscopic stent	4 m	Scalp	Nodules	WLE	No (2 weeks)
Varma et al., 2015 [52]	40	F	Adenocarcinoma	—	Colostomy	2 m	Pubic area, thigh	Nodules	NA	NA
Our case, 2018

NCR: neoadjuvant chemoradiation; CR: chemoradiation; SX: surgery; CT: chemotherapy; WLE: wide local excision; NR: neoadjuvant radiation; ACR: adjuvant chemoradiation; APR: abdominoperineal resection; LAR: low anterior resection; NA: not available.