Fatal CMV-Infection after Autologous Stem Cell Transplantation in Refractory Systemic Lupus Erythematosus

Table 1

Inclusion and exclusion criteria for autologous stem-cell transplantation in systemic lupus erythematosus.

Inclusion criteria

Exclusion criteria

(1) The diagnostic criteria for SLE are fulfilled based on the ACR guidelines; (2) Type III or IV glomerulonephritis based on the WHO classification cannot be controlled by short-term treatment with cyclophosphamide; (3) Lung and/or cardiac parenchymal destruction due to histologically proven vasculitis, if not improving to IV cyclophosphamide; (4) Encephalitis or myelitis transversa, if not improving to IV cyclophosphamide; (5) Severe refractory autoimmune cytopenia, if refractory to standard-dose treatment; (6) Catastrophic antiphospholipid syndrome

(1) Absolute neutrophil counts <2000/μL; (2) Platelet counts <120000/μL; (3) Age over 70 years; (4) Serum creatinine level is over 3,0 mg/dL; (5) Ejection fraction is below 45% by echocardiography, malignant arrhythmia, and NYHA stage IV cardiac failure; (6) Accompanying malignant disease; (7) Infection; (8) Respiratory failure; (9) Deterioration of liver functions

Abbreviations: ACR: American College of Rheumatology, WHO: World Health Organization, NYHA: New York Heart Association.