Eradication of Pulmonary Aspergillosis in an Adolescent Patient Undergoing Three Allogeneic Stem Cell Transplantations for Acute Lymphoblastic Leukemia

Figure 1

Drug regimens and development of invasive pulmonary aspergillosis (IPA). Important milestones are marked with letters: (A) Diagnosis of aspergillosis with extensive lesions in the apical right lung. (B) Improvement of lesions in the apical right lung. (C) Improvement of all lesions in the right lung with start of scarring. (D) Worsening of the lesions in the right lung and a new lesion in the left lung segment 3 under monotherapy with L-AmB or voriconazole. (E) and (F) Improvement of all lesions. (G) Progression of all lesions. (H) Almost complete disappearance of pulmonary aspergillosis. Abbreviations: HSCT, hematopoietic stem cell transplantation; L-AmB, liposomal amphotericin B; CsA, cyclosporin A; MMF, mycophenolatmofetil.