Case Report
Treatment of Acute Tacrolimus Toxicity with Phenytoin in Solid Organ Transplant Recipients
Table 2
Management of FK toxicity and outcomes.
| | Patient number | Hospital day of phenytoin initiation | Phenytoin dose (mg/day)/duration (days) | Other management | Days to FK <15 ng/mL | Days to resuming tacrolimus | Days to baseline SCr | Outcome/followup (months) |
| | 1 | 1 | 400/3 | HAART temporarily withheld | 2 | 5 | * | Alive, stable renal function/60 | | 2 | 1 | 400/2 | Fluconazole temporarily withheld | 3 | 5 | 10 | Died, cardiac arrest/7 | | 3 | 1 | 300/3 | Herbal products stopped | 3 | 4 | 10 | Alive, stable renal function/13 | | 4 | 2 | 400/3 | Voriconazole stopped | 3 | 4 | 3 | Alive, stable renal function/8 |
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Patient baseline creatinine 1.7 mg/dL did not return back to baseline but settled with creatinine of 2.2 mg/dL.
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