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Case Reports in Transplantation
Volume 2015, Article ID 356459, 4 pages
Case Report

Premalignant and Malignant Skin Lesions in Two Recipients of Vascularized Composite Tissue Allografts (Face, Hands)

1Department of Dermatology, Edouard Herriot Hospital Group, 69003 Lyon, France
2Department of Surgery, University of Cagliari, 09124 Cagliari, Italy
3Hand Surgery Department, Clinique du Parc, 69006 Lyon, France
4Department of Maxillofacial Surgery and Stomatology, University Hospital Nord, 80054 Amiens, France
5Department of Transplantation, Edouard Herriot Hospital Group, 69003 Lyon, France

Received 31 July 2015; Accepted 29 September 2015

Academic Editor: Claudia Sommerer

Copyright © 2015 Jean Kanitakis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Recipients of solid organ transplants (RSOT) have a highly increased risk for developing cutaneous premalignant and malignant lesions, favored by the lifelong immunosuppression. Vascularized composite tissue allografts (VCA) have been introduced recently, and relevant data are sparse. Two patients with skin cancers (one with basal cell carcinoma and one with squamous cell carcinomas) have been so far reported in this patient group. Since 2000 we have been following 9 recipients of VCA (3 face, 6 bilateral hands) for the development of rejection and complications of the immunosuppressive treatment. Among the 9 patients, one face-grafted recipient was diagnosed with nodular-pigmented basal cell carcinoma of her own facial skin 6 years after graft, and one patient with double hand allografts developed disseminated superficial actinic porokeratosis, a potentially premalignant dermatosis, on her skin of the arm and legs. Similar to RSOT, recipients of VCA are prone to develop cutaneous premalignant and malignant lesions. Prevention should be applied through sun-protective measures, regular skin examination, and early treatment of premalignant lesions.