De Novo Renal Cell Carcinoma in a Kidney Allograft 20 Years after Transplant

Figure 3

Pathological tissue images. (a) and (b) Allograft nephrectomy revealed that the tumor was 13 mm, Grade G2, INFb, v0, ly0, eg, fc1, im0, rc-inf1, rp-inf0, s-inf0, pT1a, pN0, pM0, and stage I. (c) and (d) On pathological examination (hematoxylin and eosin staining), the tumor was composed almost exclusively of clear cells that exhibited trabecular or papillary growth patterns in (c) low-power (10x) and (d) high-power (400x) fields. (e) and (f) An XY-fluorescence in situ hybridization (FISH) analysis performed on the kidney graft tumor revealing (e) healthy XX genotype control cells (lymphocytes) as well as (f) XX genotype cells (left) and XY genotype cells (right) in the tumor, including blood cells from the recipient. chr., chromosome.

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