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Case Reports in Transplantation
Volume 2016, Article ID 1879529, 7 pages
http://dx.doi.org/10.1155/2016/1879529
Case Report

Scedosporiosis in a Combined Kidney and Liver Transplant Recipient: A Case Report of Possible Transmission from a Near-Drowning Donor

1Department of Abdominal Transplant, Aurora St. Luke’s Medical Center, Milwaukee, WI, USA
2University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
3Department of Critical Care, Aurora St. Luke’s Medical Center, Milwaukee, WI, USA
4Weill Cornell Medicine, Cornell University and New York Presbyterian Hospital, New York, NY, USA

Received 29 August 2016; Accepted 6 November 2016

Academic Editor: Graeme Forrest

Copyright © 2016 Rachael Leek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. S. Johnson, R. K. Shields, and C. J. Clancy, “Epidemiology, clinical manifestations, and outcomes of scedosporium infections among solid organ transplant recipients,” Transplant Infectious Disease, vol. 16, no. 4, pp. 578–587, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Bose, S. Sharma, P. Derrington, and D. Divi, “Scedosporium apiospermum peritonitis in a patient undergoing peritoneal dialysis,” Nephrology, vol. 17, no. 5, pp. 521–522, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Malini, N. S. Madhusudan, S. P. Sinhasan, and B. C. Harthimath, “A masquerading subcutaneous swelling caused by Scedosporium apiospermum: an emerging pathogen,” Indian Journal of Pathology and Microbiology, vol. 58, no. 1, pp. 115–117, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. H. L. Wilson and K. J. Kennedy, “Scedosporium apiospermum brain abscesses in an immunocompetent man with silicosis,” Medical Mycology Case Reports, vol. 2, no. 1, pp. 75–78, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. J. M. Schaenman, D. B. DiGiulio, L. F. Mirels et al., “Scedosporium apiospermum soft tissue infection successfully treated with voriconazole: potential pitfalls in the transition from intravenous to oral therapy,” Journal of Clinical Microbiology, vol. 43, no. 2, pp. 973–977, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. T. J. Walsh, A. Groll, J. Hiemenz, R. Fleming, E. Roilides, and E. Anaissie, “Infections due to emerging and uncommon medically important fungal pathogens,” Clinical Microbiology and Infection, vol. 10, supplement 1, pp. 48–66, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. K. J. Cortez, E. Roilides, F. Quiroz-Telles et al., “Infections caused by Scedosporium spp,” Clinical Microbiology Reviews, vol. 21, no. 1, pp. 157–197, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. P. T. Ender and M. J. Dolan, “Pneumonia associated with near-drowning,” Clinical Infectious Diseases, vol. 25, no. 4, pp. 896–907, 1997. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Katragkou, J. Dotis, M. Kotsiou, M. Tamiolaki, and E. Roilides, “Scedosporium apiospermum infection after near-drowning,” Mycoses, vol. 50, no. 5, pp. 412–421, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. P. A. Kowacs, C. E. Soares Silvado, S. Monteiro de Almeida et al., “Infection of the CNS by Scedosporium apiospermum after near drowning. Report of a fatal case and analysis of its confounding factors,” Journal of Clinical Pathology, vol. 57, no. 2, pp. 205–207, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. M. S. Patel, A. J. Wright, R. Kohn, J. F. Markmann, C. N. Kotton, and P. A. Vagefi, “Successful long-term management of invasive cerebral fungal infection following liver transplantation,” Mycoses, vol. 58, no. 3, pp. 181–186, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. S.-H. Kim, Y. E. Ha, J.-C. Youn et al., “Fatal scedosporiosis in multiple solid organ allografts transmitted from a nearly-drowned donor,” American Journal of Transplantation, vol. 15, no. 3, pp. 833–840, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Hoetzenecker, H. J. Ankersmit, G. Lang et al., “Considerations on infectious complications using a drowned lung for transplantation,” Transplant International, vol. 23, no. 7, pp. e32–e34, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Kusne, S. Ariyanayagam-Baksh, D. C. Strollo, and J. Abernethy, “Invasive Scedosporium apiospermum infection in a heart transplant recipient presenting with multiple skin nodules and a pulmonary consolidation,” Transplant Infectious Disease, vol. 2, no. 4, pp. 194–196, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Tamm, M. Malouf, and A. Glanville, “Pulmonary scedosporium infection following lung transplantation,” Transplant Infectious Disease, vol. 3, no. 4, pp. 189–194, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. B. Castiglioni, D. A. Sutton, M. G. Rinaldi, J. Fung, and S. Kusne, “Pseudallescheria boydii (Anamorph scedosporium apiospermum) infection in solid organ transplant recipients in a tertiary medical center and review of the literature,” Medicine, vol. 81, no. 5, pp. 333–348, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. E. L. Campagnaro, K. J. Woodside, M. G. Early et al., “Disseminated Pseudallescheria boydii (Scedosporium apiospermum) infection in a renal transplant patient,” Transplant Infectious Disease, vol. 4, no. 4, pp. 207–211, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Montejo, M. L. Muñiz, S. Zárraga et al., “Infection due to Scedosporium apiospermum in renal transplant recipients: a report of two cases and literature review of central nervous system and cutaneous infections by Pseudoallescheria boydii/Sc. apiospermum,” Mycoses, vol. 45, no. 9-10, pp. 418–427, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Raj and A. E. Frost, “Scedosporium apiospermum fungemia in a lung transplant recipient,” Chest, vol. 121, no. 5, pp. 1714–1716, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. T. R. Talbot, J. Hatcher, S. F. Davis, R. N. Pierson III, R. Barton, and S. Dummer, “Scedosporium apiospermum pneumonia and sternal wound infection in a heart transplant recipient,” Transplantation, vol. 74, no. 11, pp. 1645–1647, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Fortún, P. Martín-Dávila, M. A. Sánchez et al., “Voriconazole in the treatment of invasive mold infections in transplant recipients,” European Journal of Clinical Microbiology and Infectious Diseases, vol. 22, no. 7, pp. 408–413, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Ahmed, D. M. Ditmars, T. Sheppard, R. Del Busto, K. K. Venkat, and R. Parasuraman, “Recurrence of Scedosporium apiospermum infection following renal re-transplantation,” American Journal of Transplantation, vol. 4, no. 10, pp. 1720–1724, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Reimann, E. Büssemaker, and P. Gross, “Successful treatment due to vacuum seal technique of a severe Scedosporium apiospermum skin infection in a renal transplant recipient,” Nephrology Dialysis Transplantation, vol. 19, no. 1, pp. 245–248, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. M. R. Vagefi, E. T. Kim, R. G. Alvarado, J. L. Duncan, E. L. Howes, and J. B. Crawford, “Bilateral endogenous Scedosporium prolificans endophthalmitis after lung transplantation,” American Journal of Ophthalmology, vol. 139, no. 2, pp. 370–373, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Husain, P. Muñoz, G. Forrest et al., “Infections due to Scedosporium apiospermum and Scedosporium prolificans in transplant recipients: clinical characteristics and impact of antifungal agent therapy on outcome,” Clinical Infectious Diseases, vol. 40, no. 1, pp. 89–99, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. F. Symoens, C. Knoop, M. Schrooyen et al., “Disseminated Scedosporium apiospermum infection in a cystic fibrosis patient after double-lung transplantation,” Journal of Heart and Lung Transplantation, vol. 25, no. 5, pp. 603–607, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Farina, E. Gotti, F. Suter, and A. Goglio, “Scedosporium apiospermum soft-tissue infection: a case report and review of kidney transplant literature,” Transplantation Proceedings, vol. 38, no. 5, pp. 1333–1335, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Musk, D. Chambers, W. Chin, R. Murray, and E. Gabbay, “Successful treatment of disseminated Scedosporium infection in 2 lung transplant recipients: review of the literature and recommendations for management,” Journal of Heart and Lung Transplantation, vol. 25, no. 10, pp. 1268–1272, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. P. G. Rogasi, M. Zanazzi, J. Nocentini et al., “Disseminated Scedosporium apiospermum infection in renal transplant recipient: long-term successful treatment with voriconazole: a case report,” Transplantation Proceedings, vol. 39, no. 6, pp. 2033–2035, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Sahi, R. K. Avery, O. A. Minai et al., “Scedosporium apiospermum (Pseudoallescheria boydii) Infection in lung transplant recipients,” Journal of Heart and Lung Transplantation, vol. 26, no. 4, pp. 350–356, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Y. Z. Li, T. Y. Yong, D. I. Grove, and P. T. H. Coates, “Successful control of Scedosporium prolificans septic arthritis and probable osteomyelitis without radical surgery in a long-term renal transplant recipient,” Transplant Infectious Disease, vol. 10, no. 1, pp. 63–65, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. K. Ezzedine, K. M. Wissing, F. Jacobs, H. Rodriguez, D. Malvy, and T. Simonart, “Recurrent Scedosporium apiospermum skin infection in a renal transplant recipient,” Journal of the European Academy of Dermatology and Venereology, vol. 23, no. 1, pp. 95–96, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. F. Morio, D. Horeau-Langlard, F. Gay-Andrieu et al., “Disseminated Scedosporium/Pseudallescheria infection after double-lung transplantation in patients with cystic fibrosis,” Journal of Clinical Microbiology, vol. 48, no. 5, pp. 1978–1982, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. B. Luijk, M. B. Ekkelenkamp, P. A. De Jong et al., “Effective prolonged therapy with voriconazole in a lung transplant recipient with spondylodiscitis induced by Scedosporium apiospermum,” Case Reports in Infectious Diseases, vol. 2011, Article ID 460313, 4 pages, 2011. View at Publisher · View at Google Scholar
  35. S. Hirschi, V. Letscher-Bru, J. Pottecher et al., “Disseminated Trichosporon mycotoxinivorans, Aspergillus fumigatus, and Scedosporium apiospermum coinfection after lung and liver transplantation in a cystic fibrosis patient,” Journal of Clinical Microbiology, vol. 50, no. 12, pp. 4168–4170, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. F. Miraldi, M. Anile, F. Ruberto et al., “Scedosporium apiospermum atrial mycetomas after lung transplantation for cystic fibrosis,” Transplant Infectious Disease, vol. 14, no. 2, pp. 188–191, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. C. Hartmann, C. Müller, H. Weißbrodt et al., “Successful prevention of scedosporiosis after lung transplantation in a cystic fibrosis patient by combined local and systemic triazole therapy,” Medical Mycology Case Reports, vol. 2, no. 1, pp. 116–118, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. D. M. Sayah, B. S. Schwartz, J. Kukreja, J. P. Singer, J. A. Golden, and L. E. Leard, “Scedosporium prolificans pericarditis and mycotic aortic aneurysm in a lung transplant recipient receiving voriconazole prophylaxis,” Transplant Infectious Disease, vol. 15, no. 2, pp. E70–E74, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Rathi, S. Gundlapalli, R. Ramachandran et al., “A rare case of cytomegalovirus, scedosporium apiospermum and mycobacterium tuberculosis in a renal transplant recipient,” BMC Infectious Diseases, vol. 14, article 259, 2014. View at Publisher · View at Google Scholar · View at Scopus
  40. K. Uno, K. Kasahara, S. Kutsuna et al., “Infective endocarditis and meningitis due to Scedosporium prolificans in a renal transplant recipient,” Journal of Infection and Chemotherapy, vol. 20, no. 2, pp. 131–133, 2014. View at Publisher · View at Google Scholar · View at Scopus
  41. M. E. Clement, E. K. Maziarz, J. N. Schroder, C. B. Patel, and J. R. Perfect, “Scedosporium apiosermum infection of the ‘Native’ valve: fungal endocarditis in an orthotopic heart transplant recipient,” Medical Mycology Case Reports, vol. 9, pp. 34–36, 2015. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Sharma and D. Singh, “Scedosporium apiospermum causing brain abscess in a renal allograft recipient,” Saudi Journal of Kidney Diseases and Transplantation, vol. 26, no. 6, pp. 1253–1256, 2015. View at Publisher · View at Google Scholar · View at Scopus
  43. Deceased Donors Recovered in the U.S. by Mechanism of Death: Transplant Data 1988–2015, Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation, Rockville, MD; United Network for Organ Sharing, Richmond, VA; University Renal Research and Education Association, Ann Arbor, MI.
  44. C. Goldman, M. J. Akiyama, J. Torres, E. Louie, and S. A. Meehan, “Scedosporium apiospermum infections and the role of combination antifungal therapy and GM-CSF: a case report and review of the literature,” Medical Mycology Case Reports, vol. 11, pp. 40–43, 2016. View at Publisher · View at Google Scholar
  45. M. J. Abzug and T. J. Walsh, “Interferon-γ and colony-stimulating factors as adjuvant therapy for refractory fungal infections in children,” Pediatric Infectious Disease Journal, vol. 23, no. 8, pp. 769–773, 2004. View at Publisher · View at Google Scholar · View at Scopus