Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal Allograft

Figure 2

(a) Histopathological examination of the renal allograft tumour showed eosinophilic chromophobe renal cell carcinoma. The tumour consisted of medium to large round and polygonal neoplastic cells arranged in variably sized nests and cords and poorly formed acini [H&E ×200]. (b) Tumour cells exhibited hyperchromatic nuclei, irregular “raisinoid” nuclear membranes (arrows) and voluminous, and dense eosinophilic cytoplasm [H&E ×400]. (c) Tumour cells “raisinoid,” wrinkled nuclear membranes, and perinuclear cytoplasmic clearing (arrows) [H&E ×600]. Immunophenotypically, the tumour cells exhibited positive immune reaction to pancytokeratin (CK) (d), low-molecular weight CK (e), CK7 (diffuse and strong staining, (f)), and E-cadherin (g), while staining for renal cell carcinoma (h), CD10 (i), and CD117 (j) antibodies was negative [(d–j) ×200].

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