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Case Reports in Transplantation
Volume 2017, Article ID 6401086, 5 pages
https://doi.org/10.1155/2017/6401086
Case Report

Posttransplant Lymphoproliferative Disease Presenting as an Extracranial Mass

Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA

Correspondence should be addressed to Reuben J. Arasaratnam; ude.nretsewhtuostu@mantarasara.nebuer

Received 9 May 2017; Revised 7 August 2017; Accepted 30 August 2017; Published 11 October 2017

Academic Editor: Ryszard Grenda

Copyright © 2017 Reuben J. Arasaratnam and Alejandro Restrepo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Nalesnik, R. Jaffe, J. Reyes et al., “Posttransplant lymphoproliferative disorders in small bowel allograft recipients,” Transplantation Proceedings, vol. 32, no. 6, p. 1213, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Opelz and B. Döhler, “Lymphomas after solid organ transplantation: a collaborative transplant study report,” American Journal of Transplantation, vol. 4, no. 2, pp. 222–230, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Opelz and R. Henderson, “Incidence of non-Hodgkin lymphoma in kidney and heart transplant recipients,” The Lancet, vol. 342, no. 8886-8887, pp. 1514–1516, 1993. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Hartmann, M. Schuchmann, and T. Zimmermann, “Posttransplant lymphoproliferative disease in liver transplant patients,” Current Infectious Disease Reports, vol. 13, no. 1, pp. 53–59, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. I. M. Ghobrial, T. M. Habermann, M. J. Maurer et al., “Prognostic analysis for survival in adult solid organ transplant recipients with post-transplantation lymphoproliferative disorders,” Journal of Clinical Oncology, vol. 23, no. 30, pp. 7574–7582, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Dotti, R. Fiocchi, T. Motta et al., “Lymphomas occurring late after solid-organ transplantation: influence of treatment on the clinical outcome,” Transplantation, vol. 74, no. 8, pp. 1095–1102, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Gouya, G. Hartmann, P. Faè et al., “A case of fulminant post-transplant lymphoproliferative disorder and septicemia,” Clinical Transplantation, vol. 20, no. 2, pp. 261–264, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. M. L. Nijland, M. J. Kersten, S. T. Pals, F. J. Bemelman, and I. J. ten Berge, “Epstein-barr virus–positive posttransplant lymphoproliferative disease after solid organ transplantation,” Transplantation Direct, vol. 2, no. 1, p. e48, 2016. View at Publisher · View at Google Scholar
  9. Z. Al-Mansour, B. P. Nelson, and A. M. Evens, “Post-transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and current treatment strategies,” Current Hematologic Malignancy Reports, vol. 8, no. 3, pp. 173–183, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Dierickx, T. Tousseyn, X. Sagaert et al., “Single-center analysis of biopsy-confirmed posttransplant lymphoproliferative disorder: incidence, clinicopathological characteristics and prognostic factors,” Leukemia and Lymphoma, vol. 54, no. 11, pp. 2433–2440, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. A. M. Evens, K. A. David, I. Helenowski et al., “Multicenter analysis of 80 solid organ transplantation recipients with post-transplantation lymphoproliferative disease: outcomes and prognostic factors in the modern era,” Journal of Clinical Oncology, vol. 28, no. 6, pp. 1038–1046, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. H. E. Heslop, “How I treat EBV lymphoproliferation,” Blood, vol. 114, no. 19, pp. 4002–4008, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. R. San-Juan, P. Comoli, S. Caillard, B. Moulin, H. H. Hirsch, and P. Meylan, “Epstein-Barr virus-related post-transplant lymphoproliferative disorder in solid organ transplant recipients,” Clinical Microbiology and Infection, vol. 20, supplement 7, pp. 109–118, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. C. V. Paya, J. J. Fung, M. A. Nalesnik et al., “Epstein-barr virus-induced posttransplant lymphoproliferative disorders,” Transplantation, vol. 68, no. 10, pp. 1517–1525, 1999. View at Publisher · View at Google Scholar
  15. D. P. Beynet, S. A. Wee, S. S. Horwitz et al., “Clinical and pathological features of posttransplantation lymphoproliferative disorders presenting with skin involvement in 4 patients,” Archives of Dermatology, vol. 140, no. 9, pp. 1140–1146, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. M. M. Hanasono, B. M. Parrett, and A. S. Breitbart, “Posttransplant lymphoproliferative disorder presenting as a cutaneous forehead mass,” Otolaryngology - Head and Neck Surgery, vol. 130, no. 3, pp. 372–374, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Basic-Jukic, P. Kes, L. Bubic-Filipi, and M. Coric, “An unusual case of forehead post-transplant lymphoproliferative disease,” Kidney International, vol. 73, no. 1, p. 136, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. U. D. Allen, J. K. Preiksaitis, and Practice ASTIDCo, “Epstein-Barr virus and posttransplant lymphoproliferative disorder in solid organ transplantation,” American Society of Transplant Surgeons, vol. 13, supplement 4, pp. 107–120, 2013. View at Google Scholar
  19. R. Reshef, S. Vardhanabhuti, M. R. Luskin et al., “Reduction of immunosuppression as initial therapy for posttransplantation lymphoproliferative disorder,” American Journal of Transplantation, vol. 11, no. 2, pp. 336–347, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. L. J. Swinnen, M. Leblanc, T. M. Grogan et al., “Prospective study of sequential reduction in immunosuppression, interferon alpha-2B, and chemotherapy for posttransplantation lymphoproliferative disorder,” Transplantation, vol. 86, no. 2, pp. 215–222, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. J. S. Knight, A. Tsodikov, D. M. Cibrik, C. W. Ross, M. S. Kaminski, and D. W. Blayney, “Lymphoma after solid organ transplantation: risk, response to therapy, and survival at a transplantation center,” Journal of Clinical Oncology, vol. 27, no. 20, pp. 3354–3362, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Zimmermann and R. U. Trappe, “Therapeutic options in post-transplant lymphoproliferative disorders,” Therapeutic Advances in Hematology, vol. 2, no. 6, pp. 393–407, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Zimmermann and R. U. Trappe, “EBV and posttransplantation lymphoproliferative disease: what to do?” Hematology, vol. 2013, no. 1, pp. 95–102, 2013. View at Publisher · View at Google Scholar
  24. R. Trappe, S. Oertel, V. Leblond et al., “Sequential treatment with rituximab followed by CHOP chemotherapy in adult B-cell post-transplant lymphoproliferative disorder (PTLD): the prospective international multicentre phase 2 PTLD-1 trial,” The Lancet Oncology, vol. 13, no. 2, pp. 196–206, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. R. U. Trappe, D. Dierickx, H. Zimmermann et al., “Response to rituximab induction is a predictive marker in B-cell post-transplant lymphoproliferative disorder and allows successful stratification into rituximab or r-chop consolidation in an international, prospective, multicenter Phase II trial,” Journal of Clinical Oncology, vol. 35, no. 5, pp. 536–543, 2017. View at Publisher · View at Google Scholar · View at Scopus
  26. B. M. Colby, J. E. Shaw, G. B. Elion, and J. S. Pagano, “Effect of acyclovir [9-(2-hydroxyethoxymethyl)guanine] on Epstein-Barr virus DNA replication,” Journal of Virology, vol. 34, no. 2, pp. 560–568, 1980. View at Google Scholar · View at Scopus
  27. C. S. Crumpacker, “Drug therapy: ganciclovir,” New England Journal of Medicine, vol. 335, no. 10, pp. 721–729, 1996. View at Publisher · View at Google Scholar · View at Scopus
  28. J. A. Kanakry and R. F. Ambinder, “EBV-related lymphomas: new approaches to treatment,” Current Treatment Options in Oncology, vol. 14, no. 2, pp. 224–236, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. M. A. AlDabbagh, M. R. Gitman, D. Kumar, A. Humar, C. Rotstein, and S. Husain, “The role of antiviral prophylaxis for the prevention of epstein–barr virus–associated posttransplant lymphoproliferative disease in solid organ transplant recipients: a systematic review,” American Journal of Transplantation, vol. 17, no. 3, pp. 770–781, 2017. View at Publisher · View at Google Scholar · View at Scopus
  30. K. Afshar, A. P. Rao, V. Patel, K. Forrester, and S. Ganesh, “Use of foscarnet therapy for ebv infection following control of ptld with enhancement of cellular immunity in a lung-transplant recipient,” Journal of Transplantation, vol. 2011, Article ID 919651, 4 pages, 2011. View at Publisher · View at Google Scholar
  31. S. H. Oertel, I. Anagnostopoulos, M. W. Hummel, S. Jonas, and H. B. Riess, “Identification of early antigen BZLF1/ZEBRA protein of Epstein-Barr virus can predict the effectiveness of antiviral treatment in patients with post-transplant lymphoproliferative disease,” British Journal of Haematology, vol. 118, no. 4, pp. 1120–1123, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Trappe, H. Riess, I. Anagnostopoulos et al., “Efficiency of antiviral therapy plus IVIG in a case of primary EBV infection associated PTLD refractory to rituximab, chemotherapy, and antiviral therapy alone,” Annals of Hematology, vol. 88, no. 2, pp. 167–172, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Papadopoulou, U. Gerdemann, U. L. Katari et al., “Activity of broad-spectrum T cells as treatment for AdV, EBV, CMV, BKV, and HHV6 infections after HSCT,” Science Translational Medicine, vol. 6, no. 242, Article ID 242ra83, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. A. M. Leen, C. M. Bollard, A. M. Mendizabal et al., “Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation,” Blood, vol. 121, no. 26, pp. 5113–5123, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. C. M. Bollard, C. M. Rooney, and H. E. Heslop, “T-cell therapy in the treatment of post-transplant lymphoproliferative disease,” Nature Reviews Clinical Oncology, vol. 9, no. 9, pp. 510–519, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. T. Haque, G. M. Wilkie, M. M. Jones et al., “Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trial,” Blood, vol. 110, no. 4, pp. 1123–1131, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. U. Gerdemann, U. L. Katari, A. Papadopoulou et al., “Safety and clinical efficacy of rapidly-generated trivirus-directed T cells as treatment for adenovirus, EBV, and CMV infections after allogeneic hematopoietic stem cell transplant,” Molecular Therapy, vol. 21, no. 11, pp. 2113–2121, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. M. A. Vickers, G. M. Wilkie, N. Robinson et al., “Establishment and operation of a good manufacturing practice-compliant allogeneic Epstein-Barr virus (EBV)-specific cytotoxic cell bank for the treatment of EBV-associated lymphoproliferative disease,” British Journal of Haematology, vol. 167, no. 3, pp. 402–410, 2014. View at Publisher · View at Google Scholar · View at Scopus
  39. R. J. O'Reilly, S. Prockop, A. N. Hasan, G. Koehne, and E. Doubrovina, “Virus-specific T-cell banks for 'off the shelf' adoptive therapy of refractory infections,” Bone Marrow Transplantation, vol. 51, no. 9, pp. 1163–1172, 2016. View at Publisher · View at Google Scholar · View at Scopus
  40. V. R. Dharnidharka, “Peripheral Blood Epstein–Barr Viral Nucleic Acid Surveillance as a Marker for Posttransplant Cancer Risk,” American Journal of Transplantation, vol. 17, no. 3, pp. 611–616, 2017. View at Publisher · View at Google Scholar · View at Scopus
  41. T. C. Lee, B. Savoldo, C. M. Rooney et al., “Quantitative EBV viral loads and immunosuppression alterations can decrease PTLD incidence in pediatric liver transplant recipients,” American Journal of Transplantation, vol. 5, no. 9, pp. 2222–2228, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. S. Choquet, S. Varnous, C. Deback, J. L. Golmard, and V. Leblond, “Adapted treatment of epstein-barr virus infection to prevent posttransplant lymphoproliferative disorder after heart transplantation,” American Journal of Transplantation, vol. 14, no. 4, pp. 857–866, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. N. A. Bakker, E. A. M. Verschuuren, M. E. Erasmus et al., “Epstein-Barr virus-DNA load monitoring late after lung transplantation: a surrogate marker of the degree of immunosuppression and a safe guide to reduce immunosuppression,” Transplantation, vol. 83, no. 4, pp. 433–438, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. B. Savoldo, J. A. Goss, M. M. Hammer et al., “Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs),” Blood, vol. 108, no. 9, pp. 2942–2949, 2006. View at Publisher · View at Google Scholar · View at Scopus
  45. J. K. Preiksaitis, X. L. Pang, J. D. Fox, J. M. Fenton, A. M. Caliendo, and G. G. Miller, “Interlaboratory comparison of Epstein-Barr virus viral load assays,” American Journal of Transplantation, vol. 9, no. 2, pp. 269–279, 2009. View at Publisher · View at Google Scholar · View at Scopus