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Case Reports in Transplantation
Volume 2018, Article ID 2376483, 5 pages
https://doi.org/10.1155/2018/2376483
Case Report

HSCT-GAVE as a Manifestation of Chronic Graft versus Host Disease: A Case Report and Review of the Existing Literature

Adult Blood and Marrow Transplant Program, Duke University Medical Center, Durham, NC, USA

Correspondence should be addressed to Mitchell E. Horwitz; ude.ekud@ztiwroh.llehctim

Received 16 October 2017; Revised 5 February 2018; Accepted 8 February 2018; Published 12 March 2018

Academic Editor: Carl Classen

Copyright © 2018 Michael J. Grant and Mitchell E. Horwitz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Jabbari, R. Cherry, J. O. Lough, D. S. Daly, D. G. Kinnear, and C. A. Goresky, “Gastric antral vascular ectasia: the watermelon stomach,” Gastroenterology, vol. 87, no. 5, pp. 1165–1170, 1984. View at Google Scholar · View at Scopus
  2. J. A. Rider, A. P. Klotz, and J. B. Kirsner, “Gastritis with veno-capillary ectasia as a source of massive gastric hemorrhage,” Gastroenterology, vol. 24, no. 1, pp. 118–123, 1953. View at Publisher · View at Google Scholar
  3. P. Kar, S. Mitra, J. M. Resnick, and C. F. Torbey, “Gastric antral vascular ectasia: case report and review of the literature,” Clinical Medicine & Research, vol. 11, no. 2, pp. 80–85, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. W. Novitsky, K. W. Kercher, D. R. Czerniach, and D. E. M. Litwin, “Watermelon stomach: pathophysiology, diagnosis, and management,” Journal of Gastrointestinal Surgery, vol. 7, no. 5, pp. 652–661, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. J.-L. Payen, P. Calès, J.-J. Voigt et al., “Severe portal hypertensive gastropathy and antral vascular ectasia are distinct entities in patients with cirrhosis,” Gastroenterology, vol. 108, no. 1, pp. 138–144, 1995. View at Publisher · View at Google Scholar · View at Scopus
  6. D. P. Marmaduke, J. K. Greenson, I. Cunningham, E. E. Herderick, and J. F. Cornhill, “Gastric vascular ectasia in patients undergoing bone marrow transplantation,” American Journal of Clinical Pathology, vol. 102, no. 2, pp. 194–198, 1994. View at Publisher · View at Google Scholar · View at Scopus
  7. R. W. Tobin, R. C. Hackman, M. B. Kimmey et al., “Bleeding from gastric antral vascular ectasia in marrow transplant patients,” Gastrointestinal Endoscopy, vol. 44, no. 3, pp. 223–229, 1996. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Ohashi, M. Sanaka, Y. Tu et al., “Clinical features and treatment of hematopoietic stem cell transplantation-associated gastric antral vascular ectasia,” Bone Marrow Transplantation, vol. 32, no. 4, pp. 417–421, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Kuroiwa, N. Suzuki, N. Mizue et al., “Gastric antral vascular ectasia in 2-yr-old girl undergoing unrelated cord blood stem cell transplantation,” Pediatric Transplantation, vol. 9, no. 6, pp. 788–791, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Schmidmaier, I. Bittmann, M. Götzberger, C. Straka, G. Meinhardt, and A. Eigler, “Vascular ectasia of the whole intestine as a cause of recurrent gastrointestinal bleeding after high-dose chemotherapy,” Endoscopy, vol. 38, no. 9, pp. 940–942, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. S. E. Congly, Z. H. Gao, and M. Storr, “Duodenal vascular ectasia (DUVE) associated with hematopoietic stem cell transplant,” Endoscopy, vol. 43, supplement 2, pp. E197–E198, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Fukuda, N. Kurita, T. Sakamoto et al., “Post-transplant gastric antral vascular ectasia after intra-venous busulfan regimen,” International Journal of Hematology, vol. 98, no. 1, pp. 135–138, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Hirayama, E. Azuma, A. Nakazawa, S. Iwamoto, H. Toyoda, and Y. Komada, “Simultaneous occurrence of gastric antral vascular ectasia and protein-losing enteropathy in chronic graft-versus-host disease,” International Journal of Hematology, vol. 97, no. 4, pp. 529–534, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Ito, Y. Uchida, S. Kamano, H. Kawabata, and M. Nishioka, “Clinical comparisons between two subsets of gastric antral vascular ectasia,” Gastrointestinal Endoscopy, vol. 53, no. 7, pp. 764–770, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. D. M. Chaves, P. Sakai, C. V. Oliveira, S. Cheng, and S. Ishioka, “Watermelon stomach: clinical aspects and treatment with argon plasma coagulation,” Arquivos de Gastroenterologia, vol. 43, no. 3, pp. 191–195, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. P. S. Kamath, M. Lacerda, D. A. Ahlquist, M. A. McKusick, J. C. Andrews, and D. A. Nagorney, “Gastric mucosal responses to intrahepatic portosystemic shunting in patients with cirrhosis,” Gastroenterology, vol. 118, no. 5, pp. 905–911, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Spahr, J.-P. Villeneuve, M.-P. Dufresne et al., “Gastric antral vascular ectasia in cirrhotic patients: Absence of relation with portal hypertension,” Gut, vol. 44, no. 5, pp. 739–742, 1999. View at Publisher · View at Google Scholar · View at Scopus
  18. R. H. Parrado, H. N. Lemus, P. X. Coral-Alvarado, and G. Quintana López, “Gastric antral vascular ectasia in systemic sclerosis: current concepts,” International Journal of Rheumatology, vol. 2015, Article ID 762546, 6 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Khalil, I. Zaidman, R. Bergman, R. Elhasid, and M. W. Ben-Arush, “Autoimmune complications after hematopoietic stem cell transplantation in children with nonmalignant disorders,” The Scientific World Journal, vol. 2014, Article ID 581657, 6 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. H. El-Gendy, K. S. Shohdy, G. G. Maghraby, K. Abadeer, and M. Mahmoud, “Gastric antral vascular ectasia in systemic sclerosis: where do we stand?” International Journal of Rheumatic Diseases, vol. 20, no. 12, pp. 2133–2139, 2017. View at Publisher · View at Google Scholar · View at Scopus
  21. E. Ghrenassia, J. Avouac, D. Khanna et al., “Prevalence, correlates and outcomes of gastric antral vascular ectasia in systemic sclerosis: a EUSTAR case-control study,” The Journal of Rheumatology, vol. 41, no. 1, pp. 99–105, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Manetti, E. Neumann, A. Müller et al., “Endothelial/lymphocyte activation leads to prominent CD4+ T cell infiltration in the gastric mucosa of patients with systemic sclerosis,” Arthritis & Rheumatology, vol. 58, no. 9, pp. 2866–2873, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. D. A. Papachristos, M. Nikpour, C. Hair, and W. M. Stevens, “Intravenous cyclophosphamide as a therapeutic option for severe refractory gastric antral vascular ectasia in systemic sclerosis,” Internal Medicine Journal, vol. 45, no. 10, pp. 1077–1081, 2015. View at Publisher · View at Google Scholar
  24. Y. Sherer and Y. Shoenfeld, “Autoimmune diseases and autoimmunity post-bone marrow transplantation,” Bone Marrow Transplantation, vol. 22, no. 9, pp. 873–881, 1998. View at Publisher · View at Google Scholar · View at Scopus
  25. C. M. Artlett, J. B. Smith, and S. A. Jimenez, “Identification of fetal DNA and cells in skin lesions from women with systemic sclerosis,” The New England Journal of Medicine, vol. 338, no. 17, pp. 1186–1191, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. C. M. Artlett, K. I. Welsh, C. M. Black, and S. A. Jimenez, “Fetal-maternal HLA compatibility confers susceptibility to systemic sclerosis,” Immunogenetics, vol. 47, no. 1, pp. 17–22, 1997. View at Publisher · View at Google Scholar · View at Scopus
  27. J. L. Nelson, D. E. Furst, S. Maloney et al., “Microchimerism and HLA-compatible relationships of pregnancy in scleroderma,” The Lancet, vol. 351, no. 9102, pp. 559–562, 1998. View at Publisher · View at Google Scholar · View at Scopus
  28. R. R. E. Selinger, G. B. McDonald, D. M. Hockenbery, G. Steinbach, and M. B. Kimmey, “Efficacy of neodymium:YAG laser therapy for gastric antral vascular ectasia (GAVE) following hematopoietic cell transplant,” Bone Marrow Transplantation, vol. 37, no. 2, pp. 191–197, 2006. View at Publisher · View at Google Scholar · View at Scopus