IgG4-Related Autoimmune Prostatitis: Is It an Unusual or Underdiagnosed Manifestation of IgG4-Related Disease?

Table 1

Clinical and pathologic comparison among reported cases of IgG4-related prostatitis.

#	Age	Ethnicity	Evidence of; IgG4-RD	Serum; IgG4	Symptoms	Clinical; Dx	PSA; (ng/mL)	Procedure	Rx with; steroids	Response; to Rx	Time; at Dx
Yoshimura et al., 2006 [9]
1	65	Asian	AIP, sclerosing cholangitis, sialadenitis	↑	Obstructive urinary symptoms, urinary frequency, enlarged prostate	BPH	WNL	TURP	−	I	PO
Nishimori et al., 2007 [8]
2	64	Asian	AIP	↑	Asymptomatic on admission	BPH	<0.01	NB	+	I	Post-NB
3	67	Asian	—	↑	Prostate tenderness	BPH	1.62	TURP	−	I	PO
Uehara et al., 2008 [10]
4	65	Asian	AIP	↑	NA	PC	5.5	Radical prostatectomy	−	NA	PO*
5	73	Asian	AIP	↑	Dysuria, prostate enlargement, IPSS: 20	SPC	7.2	NB	−	NA	Post-NB
6	71	Asian	AIP	↑	Dysuria, IPSS: 21	ML	1.57	NB	+	I	Post-NB
7	55	Asian	AIP	↑	Dysuria, prostate enlargement, IPSS: 12	CP	0.38	NB	+	I	Post-NB
8	73	Asian	AIP	↑	Dysuria, prostate enlargement	SPC	5.84	NB	−	NA	Post-NB
9	66	Asian	AIP	↑	Dysuria, prostate enlargement, IPSS: 18	SPC	0.1	NB	+	I	Post-NB
Hart et al., 2013 [11]
10	55	American	AIP	↑	Enlarged prostate, nocturia, hesitancy	SPC	0.67	NB	+	I	Post-NB
Bourlon et al., 2011 [4]
11	61	Latin-American	AIP, sialadenitis, LAD	WNL	Obstructive urinary symptoms, prostate enlargement, IPSS: 15	BPH	0.27–1.19	TURP	−	I	PO

AIP: autoimmune pancreatitis; BPH: Benign prostatic hyperplasia; Dx: diagnosis; FDG-PET: positron emission tomography with [¹⁸F] fluorodeoxyglucose; I: improved; LAD: lymphadenopathy; ML, NA: nonavailable; NB: needle biopsy; PC: prostate cancer; PO: status postoperative; Post-NB: postneedle biopsy; PSA: prostate specific antigen; Rx: treatment; SPC: suspicious for prostate cancer; TURP: transurethral resection of the prostate; WNL: within normal limits. *Concomitant diagnosis of prostate cancer.