Case Reports in Urology

Case Reports in Urology / 2013 / Article

Case Report | Open Access

Volume 2013 |Article ID 490638 |

Usman Najeeb Bhatty, Mohammed Hayat Ashrafi, Caroline Mary Nicholson, Ahsanul Haq, "A Rare Case of a Pure Testicular Seminoma Presenting 7 Years after a Pineal Germinoma", Case Reports in Urology, vol. 2013, Article ID 490638, 3 pages, 2013.

A Rare Case of a Pure Testicular Seminoma Presenting 7 Years after a Pineal Germinoma

Academic Editor: A. Marte
Received17 Jul 2013
Accepted06 Sep 2013
Published10 Oct 2013


Pure testicular seminomas occurring in patients with previous intracranial germ cell tumours are extremely rare. We present such a case. A 37-year-old gentleman presented to urology after previously being treated for a pineal germinoma with steroids and radiotherapy. On routine followup, he described symptoms of a testicular seminoma. This was managed surgically with radical orchidectomy. We discuss the possible causes of such an association with a review of the literature.

1. Introduction

Germ cell malignancies are common and increasing in males. However, a handful of cases have reported the rare occurrence of testicular germ cell tumours some years after initial extragonadal presentation [14]. It is generally thought that the germ cell tumour represents a second primary tumour, as opposed to metastasis. Previous reports have suggested that genetic mutations contribute to their development [57]. We present a case of a pure testicular seminoma developing in a patient 7 years after successful treatment of a pineal germinoma.

2. Case Report

A thirty-year-old man presented to the outpatient clinic with a two-month history of headaches, nausea, and vomiting. He was previously fit with no relevant family history but was a smoker. Examination revealed bilateral papilloedema, and baseline blood tests showed raised serum prolactin levels and decreased serum cortisol, FSH, and LH levels but normal serum bHCG and AFP levels.

An MRI scan of the head and spine revealed an intracranial mass measuring 3 cm × 3 cm × 3 cm. This mass compressed the cerebral aqueduct resulting in ventriculomegaly. The lesion was a large pineal germinoma confirmed histopathologically containing a small nonenhancing necrotic area (Figures 1(a) and 1(b)). There was no radiological evidence of spinal involvement.

An endoscopic third ventriculostomy was performed to reduce intracranial pressure. A ventriculoperitoneal shunt was avoided because of the risk of intra-abdominal seeding as has been described in the literature [3]. A biopsy of the mass confirmed features in keeping with a germinoma. He was commenced on dexamethasone and underwent 16 fractions of radiotherapy. The patient remained symptom-free and annual surveillance using MRI and repeat serum blood tests showed no evidence of recurrence.

Seven years later at routine followup, the patient complained of an enlargement of his left testicle. Examination confirmed a hard testicular mass. An ultrasound scan showed a heterogeneous lesion measuring approximately 40 mm × 25 mm × 31 mm, with appearances suggestive of malignancy. An urgent urological opinion was requested, and he subsequently underwent a left inguinal radical orchidectomy. Histology confirmed a classical seminoma (pT1) with no rete invasion (Figure 2). The right testis was normal. A staging CT scan ruled out nodal and distal metastatic disease. Adjuvant chemotherapy was commenced.

Posttreatment, routine PSA level was 4.6 micrograms/litre, but TRUS and prostate biopsies were negative for malignant disease. At 6-month follow up, the patient had fully recovered with no signs of recurrence.

3. Discussion

Germ cell tumours are the commonest malignancy in young men, and their prevalence is increasing [6]. Germinomas represent about 60% of all CNS tumours [8]; the pineal gland is a common site of those that are intracranial [1]. To the best of our knowledge, there are only four other reports of a pure testicular seminoma developing some years after a previous pineal germinoma [14].

All five patients with this combination of disease were initially detected after suffering symptoms of raised intracranial pressure. It may be that some patients treated for testicular seminoma also have a clinically undetectable pineal germinoma. Therefore, although this pattern of disease is rare in the literature, the actual prevalence may be higher.

It was previously understood that extragonadal germ cell tumours represented metastasis of malignant gonadal cells. On the contrary, we believe the testicular seminoma represents a second primary germ cell tumour, in keeping with recent reports. This is likely due to a mutation in the germ cell line. The extensive time interval between the two tumours presenting suggests this. Chan et al. reported a pineal germinoma occurring simultaneously with a testicular seminoma [9]. However, a widespread metastasis from a single primary tumour cannot be ruled out because of the concurrent presentation of both tumours. Alternative theories such as oncogenic factors influencing both gonadal and cranial cells have been suggested [5].

Recently, a genetic basis has been proposed for these tumours. Mutations in the KIT gene at codon 816 are associated with gonadal and extragonadal germ cell tumours [6]. Furthermore, it is thought such mutations occur very early during embryogenesis, prior to the migration of germ cells to gonadal and extragonadal locations. Coffey et al. found a KIT mutation in a patient who suffered from a pineal germinoma and a testicular seminoma [6]. Other studies have suggested a gene locus on chromosome Xq27 as a possible site for susceptibility to germ cell tumours [7]. One report describes a testicular mixed germ cell tumour arising some years after a pineal germinoma [5]. The authors state the CCND2 gene as the cause. These reports demonstrate a genetic origin for extragonadal and gonadal germ cell tumours. In order to confirm a genetic aetiology, a family study or genetic analysis would be needed. Despite this, there is increasing evidence to favour a genetic pathophysiology.

There are now a growing number of reports describing an association between intracranial and testicular germ cell tumours, with increasing evidence to confirm a genetic link. We would encourage patients who have suffered a pineal germinoma to perform regular testicular self-examinations [4]. The prognosis following pineal germinoma is very good with a reported 5-year survival rate above 90% [10]. Therefore, there should be a greater awareness amongst urologists of a possible long-term association with testicular seminomas. Genetic studies into concurrent pineal germinomas and testicular seminomas are still needed.

The patient of this case has provided written informed consent for this submission with guarantees of confidentiality (this is available upon request).

Conflict of Interests

The authors declare that they have no conflict of interests.


  1. D. S. Peat and J. E. Trowell, “Testicular seminoma in a patient with pineal germinoma,” Journal of Clinical Pathology, vol. 47, no. 8, pp. 771–772, 1994. View at: Google Scholar
  2. G. P. Trentini, A. Miaorana, and A. de Benedittis, “Metachronous seminoma of the pineal region and right testis: case report,” Applied Pathology, vol. 3, no. 3, pp. 129–133, 1985. View at: Google Scholar
  3. L. H. Chi and M. J. Deruytter, “Dual occurrence of pineal germinoma and testicular seminoma: case report and review of the literature,” Pediatric Neurosurgery, vol. 42, no. 1, pp. 38–44, 2005. View at: Publisher Site | Google Scholar
  4. A. Maity, H.-K. G. Shu, A. R. Judkins, M. J. Fisher, L. E. A. Dwyer-Joyce, and D. J. Vaughn, “Testicular seminoma 16 years after treatment for CNS germinoma,” Journal of Neuro-Oncology, vol. 70, no. 1, pp. 83–85, 2004. View at: Publisher Site | Google Scholar
  5. V. B. Silva, A. L. Azevedo, I. M. Costa, M. S. Mafra, J. L. Passos-Coelho, and J. M. Bravo-Marques, “Mixed testicular germ cell tumour in a patient with previous pineal germinoma,” Journal of Neuro-Oncology, vol. 101, no. 1, pp. 125–128, 2011. View at: Publisher Site | Google Scholar
  6. J. Coffey, R. Linger, J. Pugh et al., “Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature,” Genes Chromosomes and Cancer, vol. 47, no. 1, pp. 34–42, 2008. View at: Publisher Site | Google Scholar
  7. E. A. Rapley, G. P. Crockford, D. Teare et al., “Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours,” Nature Genetics, vol. 24, no. 2, pp. 197–200, 2000. View at: Publisher Site | Google Scholar
  8. K. R. Muir, S. E. Parkes, S. Lawson, A. K. Thomas, A. H. Cameron, and J. R. Mann, “Changing incidence and geographical distribution of malignant paediatric germ cell tumours in the West Midlands Health Authority Region, 1957-92,” British Journal of Cancer, vol. 72, no. 1, pp. 219–223, 1995. View at: Google Scholar
  9. T. K. J. Chan, A. Agius-Fernandez, S. Bashir, and P. V. Best, “Simultaneous presentation of pineal germinoma and testicular seminoma,” Eye, vol. 10, no. 5, pp. 637–639, 1996. View at: Google Scholar
  10. T. Jorsal and M. Rørth, “Intracranial germ cell tumours: a review with special reference to endocrine manifestations,” Acta Oncologica, vol. 51, no. 1, pp. 3–9, 2012. View at: Publisher Site | Google Scholar

Copyright © 2013 Usman Najeeb Bhatty et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

More related articles

961 Views | 442 Downloads | 0 Citations
 PDF Download Citation Citation
 Download other formatsMore
 Order printed copiesOrder

Related articles

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.