Sarcomatoid Carcinoma of Male Urethra with Bone and Lung Metastases Presenting as Urethral Stricture

Table 1

Sarcomatoid carcinoma in the urethra.

Authors	Patient	Symptoms and clinical findings	Location, size, and histology of tumor	Outcome
Liu & Wu [11]; 2011	50 y.o.; female	Urinary tract infection & urinary retention	3 × 1 × 1 cm tumor that was high grade papillary serous carcinoma with psammoma bodies & mesenchymal component with area of heterologous (cartilaginous) element; epithelioid tumor cells containing melanin pigment	Total cystourethrectomy, total vaginectomy, bilateral PLND, and ileal conduit urinary diversion were performed
Komai et al. [10]; 2005	78 y.o.; female	Bleeding in the region of the genitalia	Sarcomatoid carcinoma composed of SCC and spindle cell sarcoma	Urethrectomy & suprapubic cystostomy; radiation therapy of 50 Gy to recurrence site; alive at 26 mo f/u
Konno et al. [13]; 1997	61 y.o.; female	Acute urinary retention	4 × 5 × 5 cm tumor that was carcinosarcoma with heterologous differentiation with heterologous differentiation in the region of the urethra, including a carcinoma, adenocarcinoma, and partly SCC and chondrosarcoma.	Tumor excision using transperineal approach and urinary diversion by cystostomy; local radiation 50 Gy; at 12 month f/u tumor metastasis to the pelvic bone
Xu et al. [14]; 1993	83 y.o.; male	15 years after an RC for TCC, with intermittent painless bloody discharge and presence of papillary mass at external ureteral meatus	Tumor that arose from the penile urethra and invaded the glans penis and penile corpus cavernosum; tumor composed of mixed carcinoma (SCC, adenocarcinoma, TCC) and rhabdomyosarcoma	Total phallectomy, scrotectomy, orchiectomy, and urethrectomy; metastasis to right inguinal node at the time of presentation; patient died after 5 months

CT: computed tomography; SCC: squamous cell carcinoma; TCC: transitional cell carcinoma; RC: radical cystectomy.