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Case Reports in Urology
Volume 2014, Article ID 123795, 3 pages
Case Report

Bladder Perforation Secondary to Primary Systemic Amyloidosis

Department of Urology, Cedars-Sinai Medical Group, Cedars-Sinai Medical Center, 8635 West Third Street, Suite 870, Los Angeles, CA 90048, USA

Received 20 October 2014; Accepted 11 December 2014; Published 22 December 2014

Academic Editor: Tun-Chieh Chen

Copyright © 2014 Christopher J. Dru et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Amyloidosis is a disorder of protein folding characterized by extracellular aggregation and deposition of amyloid protein fibrils. Light-chain amyloidosis, also known as primary systemic amyloidosis, is the most common form of the disease. We present a case of an 84-year-old male with a history of systemic primary amyloidosis causing genitourinary, cardiac, and autonomic dysfunction who presented with hematuria and hypotension secondary to bladder perforation. He underwent open repair of a large extraperitoneal bladder defect. He ultimately died as a result of medical complications from his disease.