Primary Desmoplastic Melanoma of the Penis

Figure 2

Histologic features of primary penile desmoplastic melanoma. Low-power photomicrograph of the penile glans depicts haphazardly arranged spindle tumor cells permeating in between collagen bundles and deeply infiltrating the dermis and corpus spongiosum within. In intimate association with the spindle tumor cells are focal atypical intraepidermal melanocytic proliferation and pseudoepitheliomatous hyperplasia in the overlying epidermis (left half of the H&E). S-100 is strongly positive in the spindle tumor cells (small photo).