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Case Reports in Urology
Volume 2016, Article ID 5304324, 4 pages
Case Report

Multilocular Cystic Renal Cell Carcinoma or Cystic Nephroma?

Department of Urology, Centro Médico Nacional 20 de Noviembre, Mexico City, Mexico

Received 13 September 2016; Revised 24 November 2016; Accepted 27 November 2016

Academic Editor: Giorgio Carmignani

Copyright © 2016 Adolfo González-Serrano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The incidence of Multilocular cystic renal cell carcinoma (MCRCC) in literature is very low and confounding MCRCC with cystic nephroma (CN) is even more unusual. The aim of this report is to present a case of MCRCC and emphasize the importance of the preoperative radiologic evaluation and immunohistochemical staining confirmation to obtain an accurate diagnosis. A 73-year-old woman presented with a history of 4-month right flank pain. CT showed a Bosniak type III renal mass. After laparoscopic partial nephrectomy the initial report was cystic nephroma. Immunohistochemical staining was performed being positive for Epithelial Membrane Antigen thus changing the diagnosis to MCRCC. Multilocular cystic renal cell carcinoma cannot reliably be distinguished from cystic nephroma neither by physical examination nor by radiologic evaluation; immunohistochemical staining assay is useful to differentiate between these conditions allowing an accurate diagnosis and proper follow-up.