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Case Reports in Urology
Volume 2016, Article ID 9317567, 3 pages
Case Report

Malignant Peripheral Nerve Sheath Tumor of Prostate: A Rare Case Report and Literature Review

1Divisions of Urology, Department of Surgery, Chi Mei Medical Center, Liuying, Tainan, Taiwan
2Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan
3Division of Hematology and Oncology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan
4Divisions of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan

Received 11 July 2016; Revised 9 October 2016; Accepted 10 October 2016

Academic Editor: Giorgio Carmignani

Copyright © 2016 Kun-Lin Hsieh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A mid-aged male presented with progressive lower urinary tract symptoms (LUTS) for years. Huge prostate with low serum prostate-specific antigen (PSA) level was detected. The specimen from transurethral resection revealed surprising pathology finding as malignant peripheral nerve sheath tumor (MPNST). Considering its huge size (more than 300 gm) and location, we prescribed neoadjuvant chemotherapy firstly. The tumor became regressive and then radical surgical resection was achieved. Adjuvant multimodality treatment including concurrent chemoradiotherapy (CCRT) and target therapy was given. However, he expired about one year later. MPNST originating from prostate is very rare and seldom reported before. We here present this extremely rare disease and share our treatment experience.