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Case Reports in Urology
Volume 2017 (2017), Article ID 7083451, 3 pages
Case Report

Hyper IgE Syndrome and Renal Cell Carcinoma

Department of Urology, New York Medical College, Valhalla, NY, USA

Correspondence should be addressed to Neel H. Patel

Received 3 March 2017; Accepted 26 April 2017; Published 18 May 2017

Academic Editor: Sandhya Srinivas

Copyright © 2017 Neel H. Patel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hyper IgE Syndrome (HIES) is an immunodeficiency disorder characterized by increased serum levels of IgE, eczema, and recurrent cutaneous and pulmonary infections. In this report, we present, to our knowledge, the first documented case of renal cell carcinoma (RCC) found in a patient with HIES. The patient received infectious disease clearance prior to obtaining a partial nephrectomy which revealed clear cell histology. Both HIES and RCC have an immunological basis for their pathophysiology and may involve common pathways. Further studies may provide insight into any possible link and clinicians should be mindful of immunocompromised patients who present with risk factors for genitourinary malignancy.