Pathologic Complete Response to Neoadjuvant Nivolumab/Ipilimumab in a Patient with Metastatic Renal Cell Carcinoma

Figure 2

Fine needle aspiration from retroperitoneal lymph node biopsy. (a) Cytologic preparation (40x magnification) showing abundant large, pleomorphic tumor cells consistent with renal cell carcinoma. Small lymphocytes and neutrophils are present in the background for scale. (b) Cell block (20x magnification) demonstrating tumor cells with significant nuclear pleomorphism. Some cells have rhabdoid features with an eccentric nucleus and abundant eosinophilic cytoplasm. (c) PAX8 immunohistochemical staining is positive in the tumor cells, highlighting the renal origin.

(a)

(b)

(c)