Near-Miss Diagnoses of Solitary Bladder Tumors Highlight the Importance of Immunohistochemical Staining

Figure 1

Negative GATA3 and positive NKX3.1 staining confirms prostatic adenocarcinoma. Low power view of the bladder tumor in (a) shows a normal urothelial mucosa and tumor beneath the urothelium, involving the submucosa. Underlying invasion of the muscularis propria was also present. (b) Strong diffuse nuclear staining with the immunohistochemical stain NKX3.1 was seen. Note the surface urothelium is negative. (c) The tumor cells are negative for the immunohistochemical stain GATA3, while the surface benign urothelium shows positive nuclear staining.

(a)

(b)

(c)