Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy

Figure 1

(a) A focus of Gleason GG2 prostatic adenocarcinoma on a targeted core in the 2^nd biopsy; (b) T2-weighted image shows lenticular homogeneous moderately hypointense lesion (arrow) measuring 1.5 cm located in right anterior transitional zone in midgland, representative of Prostate Imaging Reporting and Data System category 5; (c) apparent diffusion coefficient map shows marked focal hypointensity (arrow); (d) a single focus of Gleason GG4 prostatic adenocarcinoma on a systematic core in the 3^rd biopsy; (e) infiltrative growth of Gleason GG3 prostatic adenocarcinoma on a systematic core in the 3^rd biopsy. Gleason pattern 3 is comprised of well-formed glands with relatively clear cytoplasm, small nuclei, and inconspicuous nucleoli. Gleason pattern 4 is made up of smaller, poorly formed glands with amphophilic cytoplasm, larger nuclei, and variably prominent nucleoli; (f) a radical prostatectomy specimen showing two distinct patterns of prostatic adenocarcinoma (the majority of Gleason pattern 3 and small population of pattern 4).

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