Clear Cell Adenocarcinoma of the Ureter Similar to Clear Cell Renal Cell Carcinoma Histology

Figure 2

Pathological findings. Histopathological findings reveal that urothelial carcinoma in situ ((a) UC) persisted in part; however, most of the tumor is clear cell adenocarcinoma ((a) CCA) ((a) hematoxylin and eosin). The clear cell adenocarcinoma lesion has clear cytoplasm with round nuclei and visible nucleoli in an insular arrangement. No transitional lesion between clear cell adenocarcinoma and urothelial carcinoma can be presented in this lesion. The clear cell adenocarcinoma lesion is CK7 negative (b), CK5/6 negative (c), CK20 negative (d), GATA3 negative (e), and HNF4α positive (f). The urothelial cancer lesion is CK7 positive (b), CK5/6 weak positive (c), CK20 positive (d), GATA3 positive (e), and HNF4α negative (f). CCA: clear cell adenocarcinoma; UC: urothelial carcinoma.