Case Reports in Vascular Medicine

Case Reports in Vascular Medicine / 2017 / Article

Case Report | Open Access

Volume 2017 |Article ID 3548271 |

Francesco Giurazza, Fabio Corvino, Andrea Paladini, Antonio Borzelli, Domenico Scognamiglio, Giulia Frauenfelder, Giuseppe Albano, Fabio Sirimarco, Raffaella Niola, "Uterine Arteriovenous Fistula with Concomitant Pelvic Varicocele: Endovascular Embolization with Onyx-18®", Case Reports in Vascular Medicine, vol. 2017, Article ID 3548271, 5 pages, 2017.

Uterine Arteriovenous Fistula with Concomitant Pelvic Varicocele: Endovascular Embolization with Onyx-18®

Academic Editor: Muzaffer Sindel
Received19 Jul 2017
Accepted12 Sep 2017
Published22 Nov 2017


Uterine arteriovenous fistulas are rare and acquired causes of life-threatening vaginal bleeding. They usually present with intermittent menometrorrhagia in young patients in childbearing age with history of gynecological procedures on uterus. Traditional management is hysterectomy; endovascular embolization represents nowadays an alternative strategy for patients wishing to preserve fertility. Here, the endovascular approach to a 29-year-old woman affected by severe menometrorrhagia caused by a uterine arteriovenous fistula with a concomitant pelvic varicocele is reported; a bilateral uterine arteries embolization with Onyx-18 (ev3, Irvine, CA, USA) has successfully resolved the fistula with clinical success.

1. Introduction

A uterine arteriovenous fistula (AVF) is a rare acquired cause of life-threatening vaginal bleeding; it may be the result of trauma or surgical intervention or may be acquired in the setting of a preexisting pathologic uterine process [1].

Here, the endovascular approach to a 29-year-old woman affected by severe menometrorrhagia caused by an AVF with a concomitant pelvic varicocele is reported; the lesion has been resolved with a bilateral uterine arteries embolization (UAE) by Onyx-18 (ev3, Irvine, CA, USA) injection.

2. Case Report

A 29-year-old woman presented with severe vaginal bleeding in emergency room with a value of 7 g/dl of hemoglobin.

She reported episodes of severe menometrorrhagia during the previous 4 months.

Her clinical history presented multiple interventions on the uterus: a hysteroscopic ablation 5 years previously to remove a pedunculated lesion (histological exam: pedunculated leiomyoma), a successful pregnancy with cesarean Section 3 years previously, and a uterine curettage to remove an ectopic cervical pregnancy 4 months before hospital recovery and just before clinical presentation.

During the hospital stay, she underwent a suprapubic ultrasound (US) examination revealing a high flow vascular lesion involving the uterine wall; a contrast-enhanced Magnetic Resonance (MR) (Figures 1(a) and 1(b)) showed multiple ectatic and serpiginous anomalous vessels adjacent to the uterine wall bilaterally. Vessels enhancement is appreciable after contrast injection in Figure 1(b); a contrast-enhanced Computed Tomography (CT) (Figures 1(c) and 1(d)) showed an abnormal arterious vascular network involving the uterus with concomitant pelvic varicocele; both uterine arteries supplied the lesion with aberrant venous outflow.

The beta human Chorionic Gonadotropin (hCG) test was negative.

According to laboratory and radiological data, considering even the previous multiple uterine interventions, the diagnosis of uterine AVF was proposed.

Because of the young age of the patient and the will of future pregnancies, conventional surgery consisting of hysterectomy was avoided and a conservative endovascular approach was considered as first option.

The patient underwent a bilateral superselective UAE (Figure 2); the procedure was performed with a monolateral access by positioning a 5Fr sheath into the right common femoral artery. First, an aortogram and a pelvic angiogram using a 5Fr pigtail catheter were acquired and confirmed the high-flow AVF, excluding the involvement of arteries originating from body districts other than the hypogastric trunk (Figure 2(a)). A selective hypogastric arteriogram was obtained bilaterally, using a 5Fr Cobra curve for the (left) contralateral artery (Figure 2(b)) and a 5Fr Robert Uterine Catheter Curve for the (right) homolateral artery (Figure 2(c)): these demonstrated that both uterine arteries refurnished the fistula, with a major component from the left side; no other vessels were involved, confirming the findings of CT and MR.

Based on the diagnostic angiograms, the embolization of both uterine arteries was planned during the same session.

The most distal portion of the uterine arteries was superselectively reached with a microcatheter using a coaxial technique; the 5Fr catheter was positioned at the origin of the uterine artery and the microcatheter was advanced distally over the horizontal segment of the uterine artery; the diagnostic angiogram showed the venous outflow directly communicating with arterious inflow, confirming the fistula diagnosis.

The embolization was performed using a definitive liquid agent (Onyx-18) (Figures 2(d) and 2(e)); first, an Onyx cast was injected around the microcatheter tip to avoid nontarget reflux and then the embolizing Ethylene Vinyl Alcohol copolymer was slowly injected and pushed forward by Dimethyl Sulfoxide.

The final angiographic control (Figure 2(f)) showed completed embolization of both uterine arteries up to the FAV nidus with consequent disappearance of the venous outflow.

The patient was monitored for 5 days with nonsteroid anti-inflammatory medication because of a mild postembolization syndrome and then was dismissed.

The MR follow-up after 30 days showed resolution of the fistula with consequent disappearance of the varicocele; uterine vascularization was preserved without signs of necrosis (Figure 3).

No other episodes of menometrorrhagia occurred during the 3-month clinical follow-up and the period returned to normal 1 month after embolization.

3. Discussion

Uterine arteriovenous malformations can be congenital or acquired; the latter are named AVFs and are more common than congenital lesions that on the other hand should be properly named as arteriovenous malformations (AVM) [1].

The correct diagnosis of uterine AVF is based on negative hCG test and imaging of abnormal uterine vascular network with tortuous and serpiginous vessels [2]. Clinically, these are symptomatic patients for menometrorrhagia: bleeding is intermittent and torrential due to the differential pressure gradient across arterial and venous systems [2]. Women are typically in childbearing age with a history of uterine trauma secondary to gynecological procedures [3].

The traditional treatment is hysterectomy [4]; however, endovascular embolization represents nowadays an alternative strategy for patients wishing to preserve fertility.

The first conservative treatment for uterine AVF has been reported in 1982 [5]; since then few cases of embolization [110] have been described.

As for AVF or AVM from other body districts, it is crucial to recognize and embolize all the arterious feeders; typically uterine AVFs do not present with extrauterine involvement and are fed only by uterine arteries [1].

The technical success should always be related to the clinical success because AVF frequently relapses [7]; therefore, long-term clinical and radiological postprocedural follow-up is recommended, almost up to three months.

The risk of uterine necrosis should be considered after definitive UAE; however, the vascularization is usually supplied by the wide uterine collaterals network, as ovarian, spinal, epigastric, and hypogastric arterial branches [11].

Different embolizing agents, as coils, Spongel, particles, and glue alone or in combination, have been proposed [110]; overall embolization presents a primary success rate of 61% and secondary success rate of 91% after repeated embolization [1].

Only one paper [2] recently reported Onyx as single agent for the treatment of uterine AVF; in the presented case, embolization with Onyx-18 resolved both the FAV and the concomitant pelvic varicocele after a single procedural session.

There is no consensus about the best embolizing agent and there are also no technical guidelines because uterine AVF is a rare entity; however, endovascular conservative management should be considered as an alternative to hysterectomy in order to preserve fertility in young women wishing for future pregnancies.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent was obtained from all individual participants included in the study.

Conflicts of Interest

The authors declare that they have no conflicts of interest.


  1. D. Yoon, M. Jones, J. Taani, C. Buhimschi, and J. Dowell, “A systematic review of acquired uterine arteriovenous malformations: pathophysiology, diagnosis, and transcatheter treatment,” American Journal of Perinatology Reports, vol. 06, no. 01, pp. e6–e14, 2016. View at: Publisher Site | Google Scholar
  2. P. Barral, M. Saeed-Kilani, F. Tradi et al., “Transcatheter arterial embolization with ethylene vinyl alcohol copolymer (Onyx) for the treatment of hemorrhage due to uterine arteriovenous malformations,” Diagnostic and Interventional Imaging, vol. 98, no. 5, pp. 415–421, 2017. View at: Publisher Site | Google Scholar
  3. R. M. Grivell, K. M. Reid, and A. Mellor, “Uterine arteriovenous malformations: a review of the current literature,” Obstetrical & Gynecological Survey, vol. 60, no. 11, pp. 761–767, 2005. View at: Publisher Site | Google Scholar
  4. D. Yokomine, M. Yoshinaga, Y. Baba et al., “Successful management of uterine arteriovenous malformation by ligation of feeding artery after unsuccessful uterine artery embolization,” Journal of Obstetrics and Gynaecology Research, vol. 35, no. 1, pp. 183–188, 2009. View at: Publisher Site | Google Scholar
  5. L. Forssman, J. Lundberg, and T. Scherstén, “Conservative Treatment of Uterine Arteriovenous Fistula,” Acta Obstetricia et Gynecologica Scandinavica, vol. 61, no. 1, pp. 85–87, 1982. View at: Publisher Site | Google Scholar
  6. N. Singh, R. Tripathi, Y. M. Mala, S. Tyagi, S. Tyagi, and C. Singh, “Varied presentation of uterine arteriovenous malformations and their management by uterine artery embolisation,” Journal of Obstetrics & Gynaecology, vol. 34, no. 1, pp. 104–107, 2014. View at: Publisher Site | Google Scholar
  7. S. Ghai, D. K. Rajan, M. R. Asch, D. Muradali, M. E. Simons, and K. G. TerBrugge, “Efficacy of embolization in traumatic uterine vascular malformations,” Journal of Vascular and Interventional Radiology, vol. 14, no. 11, pp. 1401–1408, 2003. View at: Publisher Site | Google Scholar
  8. S. M. Kim, H. Y. Ahn, M. J. Choi et al., “Uterine arteriovenous malformation with positive serum beta-human chorionic gonadotropin: Embolization of both uterine arteries and extra-uterine feeding arteries,” Obstetrics & Gynecology Science, vol. 59, no. 6, pp. 554–558, 2016. View at: Publisher Site | Google Scholar
  9. A. C. Picel, S. J. Koo, and A. C. Roberts, “Transcatheter arterial embolization with n-Butyl cyanoacrylate for the treatment of acquired uterine vascular malformations,” CardioVascular and Interventional Radiology, vol. 39, no. 8, pp. 1170–1176, 2016. View at: Publisher Site | Google Scholar
  10. Z. Wang, J. Chen, H. Shi et al., “Efficacy and safety of embolization in iatrogenic traumatic uterine vascular malformations,” Clinical Radiology, vol. 67, no. 6, pp. 541–545, 2012. View at: Publisher Site | Google Scholar
  11. R. Niola, F. Giurazza, G. Nazzaro et al., “Uterine Artery Embolization before Delivery to Prevent Postpartum Hemorrhage,” Journal of Vascular and Interventional Radiology, vol. 27, no. 3, pp. 376–382, 2016. View at: Publisher Site | Google Scholar

Copyright © 2017 Francesco Giurazza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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