Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Vascular Medicine
Volume 2019, Article ID 7606727, 5 pages
Case Report

Slippery Stents: A Case Report and Review of the Literature Describing Patients with May-Thurner Syndrome That Experienced Stent Migration

1Department of Internal Medicine, Beaumont Health System, Royal Oak, MI, USA
2Oakland University William Beaumont School of Medicine, Rochester Hills, MI, USA

Correspondence should be addressed to Ramy Mando; gro.tnomuaeb@odnam.ymar

Received 24 November 2018; Revised 17 February 2019; Accepted 19 February 2019; Published 5 March 2019

Academic Editor: Nilda Espinola-Zavaleta

Copyright © 2019 Ramy Mando et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Endovascular stent placement is an effective treatment for relieving chronic venous obstruction in patients with May-Thurner Syndrome (MTS) with or without the presence of thrombotic lesions. Stent migration is a rare but potentially life-threatening complication of endovascular stenting. Herein, we describe a case of stent migration from the left common iliac vein into the right heart, requiring open-heart surgery. We also completed a literature review of MTS patients with stent migration in hopes of raising awareness of this rare and life-threatening complication.

1. Introduction

May-Thurner Syndrome was first described in 1908 and was not completely understood until the mid-1900s [1, 2]. The majority of cases described in the literature identify MTS as compression of the left common iliac vein by the right common iliac artery against the lumber vertebrae; however, variants do exist; for example, compression of the inferior vena cava by the right iliac artery has been described and also termed NIVL or nonthrombotic iliac vein lesions [35]. Therefore, MTS has been described as an obstruction of venous outflow anatomically secondary to arterial compression in the iliocaval region.

While many patients with MTS present with left lower extremity deep vein thrombosis (DVT), symptoms can include swelling, pain, claudication, ulcerations, varicose veins, and pelvic congestion syndrome [6, 7]. The use of stents in MTS has been found to be safe and efficacious for patients with postthrombotic syndrome, as well as those presenting with edema [8]. Stent migration is a rare, but potentially fatal complication of the procedure. Few cases of stent migration from iliac veins to the heart have been reported [911]. Here we present a case of stent migration to the heart following placement in the left iliac vein for treatment of May-Thurner syndrome.

2. Case Description

A 62-year-old female presented for evaluation of recurrent left lower extremity swelling. Her medical history was notable for prior deep vein thrombus in the right distal lower extremity while on hormone replacement therapy (HRT). She denied the active use of HRT and tobacco use during this admission. Venous Doppler ultrasound completed in the emergency room revealed extensive thrombosis of the left lower extremity extending superiorly towards the left common iliac vein. Further imaging with ultrasound revealed compression of the left iliac vein by the right iliac artery as well as a significantly elevated reflux time of the left great saphenous vein (14.2 seconds) suggestive of MTS. The patient was taken to the operating suite and during the procedure the common iliac vein appeared normal distally, but more proximally the vein was narrowed significantly to a diameter of less than 2 mm. Prior to entering the inferior vena cava, the common iliac vein normalized. Using intravenous ultrasound, measurements were taken and a 14 x 60 mm Luminexx stent was deployed at the area of stenosis. The stent was noted to have migrated upward into the inferior vena cava and a buttressing of this stent with a 16 x 40 mm Wallstent was placed to ensure adequate apposition. Unfortunately, this caused further migration upward into the IVC and a 14 mm Atlas balloon was used to help secure the migrated IVC stent. The area of stenosis was no longer stented given this migration. Therefore, stenting of the left common iliac vein stenosis was ultimately achieved with a 14 x 80 mm Luminexx stent (Figure 1(a)). The patient was started on warfarin with heparin bridging postoperatively. Early ambulation and the routine use of elastic stockings were encouraged following the procedure. The following day the patient complained of severe abdominal pain and an abdominal x-ray revealed only two stents located in the abdomen (Figure 1(b)). A chest x-ray was obtained and revealed the initial 14 x 60 mm Luminexx stent projecting over the right atrium (Figure 1(c)). She underwent open-heart surgery for stent retrieval and had a postoperative course complicated by atrial fibrillation and recurrent left sided lower extremity DVT managed with catheter directed thrombolysis. Hypercoagulable work-up revealed homozygosity of the Factor V Leiden gene mutation. One week after discharge, she developed hypotension and lightheadedness. She presented to the emergency department and was found to have pericardial tamponade requiring blood transfusion, pericardiocentesis, and pericardial window. Anticoagulation treatment was stopped during hospital stay and not resumed upon discharge.

Figure 1

Three weeks later, she had a syncopal episode secondary to a massive pulmonary embolus (PE). Imaging also revealed residual DVT in bilateral lower extremities. She underwent thrombolysis with tissue plasminogen activator and subsequently developed a thoracic hematoma. Given the residual clot burden in the bilateral lower extremity, she underwent IVC filter placement and mechanical thrombectomy. No additional stents were placed. Throughout the hospitalization the patient required multiple blood products after developing a hematoma related to recent thoracic surgery. The patient was eventually stabilized and given the Factor V Leiden mutation and life-threatening PE, she was started on rivaroxaban indefinitely. Since these events, she has been followed closely as an outpatient with no known hospitalizations related to bleeding or thrombosis. At 5-year follow-up, the patient reports that she is doing well. She is not experiencing any complications related to rivaroxaban. She does have residual postthrombotic syndrome (CEAP class 3, Villalta Score 8) well managed with daily compression stockings.

3. Literature Review

A systematic review of PubMed and MEDLINE was performed without any search restrictions. We used the keywords “stent”, “migration”, “iliocaval obstruction”, “iliac vein compression”, “iliac stent”, and “May Thurner”. We screened the reference sections of the eligible results for any potential missed cases of relevance to ensure the inclusion of all reported cases of stent migration in patients with MTS treated with endovascular stenting. Our search yielded six manuscripts. All manuscripts (four out of six results) describing cases of stent migration were included in our review and are summarized in Table 1.

Table 1: Characteristics and outcomes of patients with MTS and stent migration.

The literature review is notable for varying frequencies of stent migration ranging from 1.4 to 6.25% [1214]. Three patients (out of 11 patients total) were identified in the literature review as having stent migration to the heart [9, 11, 12]. One patient was managed initially with open-heart surgery for stent retrieval. Initial snare recovery of the stent was attempted in two patients; one resulted in stent fracture and subsequent open-heart surgery [9] and one patient had an uncomplicated retrieval. All patients who underwent open-heart surgery (3/11) experienced significant postoperative complications including stroke, atrial fibrillation, tamponade, chord rupture, and leaflet damage requiring valve replacement in some instances [9, 11, 12]. There was no associated mortality with any of these procedures.

4. Discussion

Our case describes a patient with MTS that presented with an acute deep vein thrombosis that was treated with endovascular stenting and, following stent placement, experienced stent migration to the heart and subsequent open-heart surgery for stent retrieval. Her postoperative course was complicated primarily by cardiac tamponade, massive pulmonary emboli, and recurrent DVTs. Our literature review highlights the significant morbidity associated with open-heart surgery and strongly favors stent retrieval utilizing snares. Overall, this case highlights the necessity for establishing a standardized safe management algorithm for patients with MTS. Furthermore, it highlights the importance of assessing risk associated with each treatment option and the clinicians’ responsibility to be prepared for complications related to all procedures to help ensure patient safety.

There is currently no expert consensus or guidelines available to the medical community to help direct the management of this condition. Therapeutic options for MTS complicated by acute DVT or postthrombotic syndrome described in the literature include endovenous treatment with endovascular stenting, catheter-directed thrombolysis, pharmacologic thrombolysis, and surgical exploration of the lesion with thrombectomy and decompression of the vein. Overall, several case reports and retrospective reviews have exhibited that endovascular, minimally invasive techniques are relatively safe and provide good symptomatic improvement [1618]. When compared to oral anticoagulation alone, catheter-directed thrombolysis has been shown to be superior with regard to resolution of the thrombus and rates of postthrombotic syndrome [18]. With regard to angioplasty, endovascular stenting appears to have a role in patients with MTS, irrespective of the presence of acute thrombus [1922].

Symptoms related to complicated MTS include lower extremity swelling, venous claudication, chronic venous insufficiency, pulmonary embolism, and pelvic congestion syndrome. We believe MTS to be underdiagnosed clinically. We feel that part of the reason this condition is underdiagnosed clinically may be due to lack of physician awareness of this pathology. It is important to recognize these patients as treatment options are available to them which may relieve many of their symptoms and prevent symptom recurrence. Although management options appear straightforward, it is also important for clinicians to recognize potential complications related to treatment, particularly stent migration. Other complications related to stent placement include thrombosis, stenosis, and fracture. Stent migration, however, may lead to the greatest morbidity in these patients, as seen in our case. We also note that proximal migration of the stent within the vessel may occur and appears to be well managed with simultaneous placement of another stent which overlaps the distal portion of the proximally migrated stent [13, 14]. Our case of stent migration to the heart is the fourth case in the literature. Overall of these four cases, two patients underwent heart surgery for stent recovery, one stent retrieval was successfully completed with snare and one failed snare retrieval and underwent heart surgery [9, 11]. Given the significant complications associated with surgical retrieval (atrial fibrillation, stroke, tamponade, leaflet destruction, and chord rupture), we feel that initial recovery attempts should be with snares and surgical recovery should be reserved for those who fail this therapy. One suggestion, which may help avoid this significant complication, may be the use of self-expanding bare metal stents as these typically provide better apposition against the vessel wall given their superior flexibility [12].

5. Conclusion

Stent migration may occur in as many as 6.25% of cases and typically leads to significant morbidity if retrieval requires open-heart surgery. We recommend the use of a snare for stent retrieval as this appears to be associated with far fewer complications when compared to open heart surgery based on the limited reports available.

Conflicts of Interest

The authors declare that they have no conflicts of interest.


The authors would like to recognize the contributions of Dr. Rashpal Sandhu for his work optimizing radiographic images and providing relevant case information from his home institution.


  1. R. May and J. Thurner, “The cause of the predominantly sinistral occurrence of thrombosis of the pelvic veins,” Angiology, vol. 8, no. 5, pp. 419–427, 1957. View at Publisher · View at Google Scholar · View at Scopus
  2. F. B. Cockett, M. L. Thomas, and D. Negus, “Iliac Vein compression.—its relation to iliofemoral thrombosis and the post-thrombotic syndrome,” British Medical Journal, vol. 2, no. 5543, pp. 14–19, 1967. View at Publisher · View at Google Scholar · View at Scopus
  3. R. M. Burke, S. S. Rayan, K. Kasirajan, E. L. Chaikof, and R. Milner, “Unusual case of right-sided May-Thurner syndrome and review of its management,” Vascular, vol. 14, no. 1, pp. 47–50, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Abboud, M. Midulla, C. Lions et al., “"Right-sided" May-Thurner syndrome,” CardioVascular and Interventional Radiology, vol. 33, no. 5, pp. 1056–1059, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. J. B. Steinberg and M. A. Jacocks, “May-Thurner syndrome: a previously unreported variant,” Annals of Vascular Surgery, vol. 7, no. 6, pp. 577–581, 1993. View at Publisher · View at Google Scholar · View at Scopus
  6. M.-G. Knuttinen, S. Naidu, R. Oklu et al., “May-Thurner: diagnosis and endovascular management,” Cardiovascular Diagnosis and Therapy, vol. 7, pp. S159–S164, 2017. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Rastogi, N.-K. Kabutey, and D. Kim, “Incapacitating pelvic congestion syndrome in a patient with a history of May-Thurner syndrome and left ovarian vein embolization,” Annals of Vascular Surgery, vol. 26, no. 5, pp. 732.e7–732.e11, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. E. S. Hager, T. Yuo, R. Tahara et al., “Outcomes of endovascular intervention for May-Thurner syndrome,” Journal of Vascular Surgery: Venous and Lymphatic Disorders, vol. 1, no. 3, pp. 270–275, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Elmahdy, C. C. Shults, and M. Alhaj Moustafa, “An unusual cause of acute heart failure: a case report of iliocaval venous stent migration,” Journal of Investigative Medicine High Impact Case Reports, vol. 6, Article ID 232470961879911, 2018. View at Publisher · View at Google Scholar
  10. T. Holst, T. Großwendt, M. Laham, M. Roosta-Azad, A. Zandi, and M. Kamler, “Acute stent migration into the right ventricle in a patient with iliac vein stenting,” The Thoracic and Cardiovascular Surgeon Reports, vol. 7, no. 1, pp. e7–e8, 2018. View at Publisher · View at Google Scholar
  11. W. Mullens, J. De Keyser, A. Van Dorpe et al., “Migration of two venous stents into the right ventricle in a patient with May-Thurner syndrome,” International Journal of Cardiology, vol. 110, no. 1, pp. 114-115, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Huang, G. Yu, and J. Huang, “Midterm results of endovascular treatment for iliac vein compression syndrome from a single center,” Annals of Vascular Surgery, vol. 49, pp. 57–63, 2018. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Ye, X. Lu, W. Li et al., “Long-term outcomes of stent placement for symptomatic nonthrombotic iliac vein compression lesions in chronic venous disease,” Journal of Vascular and Interventional Radiology, vol. 23, no. 4, pp. 502-503, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. Z. Liu, N. Gao, L. Shen et al., “Endovascular treatment for symptomatic iliac vein compression syndrome: a prospective consecutive series of 48 patients,” Annals of Vascular Surgery, vol. 28, no. 3, pp. 695–704, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. O. Hartung, A. Otero, M. Boufi et al., “Mid-term results of endovascular treatment for symptomatic chronic nonmalignant iliocaval venous occlusive disease,” Journal of Vascular Surgery, vol. 42, no. 6, pp. 1138–1144, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Y. Mousa, M. Broce, M. Yacoub, and A. F. Aburahma, “Iliac vein interrogation augments venous ulcer healing in patients who have failed standard compression therapy along with pathological venous closure,” Annals of Vascular Surgery, vol. 34, pp. 144–151, 2016. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Raju and M. Davis, “Relative importance of iliac vein obstruction in patients with post-thrombotic femoral vein occlusion,” Journal of Vascular Surgery: Venous and Lymphatic Disorders, vol. 2, no. 1, p. 107, 2014. View at Publisher · View at Google Scholar
  18. L. Watson, C. Broderick, and M. P. Armon, “Thrombolysis for acute deep vein thrombosis,” Cochrane Database of Systematic Reviews, vol. 11, Article ID Cd002783, 2016. View at Publisher · View at Google Scholar
  19. O. Ahmed, J. Ng, M. Patel et al., “Endovascular stent placement for May-Thurner syndrome in the absence of acute deep vein thrombosis,” Journal of Vascular and Interventional Radiology, vol. 27, no. 2, pp. 167–173, 2016. View at Publisher · View at Google Scholar · View at Scopus
  20. N. H. Patel, K. R. Stookey, D. B. Ketcham, and A. H. Cragg, “Endovascular management of acute extensive iliofemoral deep venous thrombosis caused by may-thurner syndrome,” Journal of Vascular and Interventional Radiology, vol. 11, no. 10, pp. 1297–1302, 2000. View at Publisher · View at Google Scholar · View at Scopus
  21. G. J. O'Sullivan, C. P. Semba, C. A. Bittner et al., “Endovascular management of iliac vein compression (May-Thurner) syndrome,” Journal of Vascular and Interventional Radiology, vol. 11, no. 7, pp. 823–836, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Juhan, O. Hartung, Y. Alimi, P. Barthélemy, N. Valerio, and F. Portier, “Treatment of nonmalignant obstructive iliocaval lesions by stent placement: mid-term results,” Annals of Vascular Surgery, vol. 15, no. 2, pp. 227–232, 2001. View at Publisher · View at Google Scholar · View at Scopus