Early Stage of Chronic Kidney Disease with Renal Injury Caused by Hypertension in a Dog
Figure 1
Light micrographs in renal biopsy analysis. (a) Periodic acid methenamine-silver stain; collapse of glomerular tufts, wrinkling of glomerular basement membrane (GBM), and thickening of Bowman’s capsule are observed. (b) Masson’s trichrome stain; severe interstitial fibrosis is observed. Most of the tubular epithelia are flattened, and their lumens are filled with casts. Hyaline degeneration, luminal narrowing, and thickening of the tunica media are seen in a small artery (arrow). (c) IgM detection; granular positive-signals are observed in the capillary wall and mesangial area in the glomeruli. Internal elastic membrane of the small artery shows a positive reaction. (d) Complement C3 detection; linear positive signals are observed in the glomeruli. Bars; 50 (a, c, and d) and 100 (b) μm.
