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Case Reports in Veterinary Medicine
Volume 2012, Article ID 596593, 6 pages
Case Report

Primary Corneal Squamous Cell Carcinoma in a Dog: Clinical and Histopathological Evaluation

1Department of Veterinary Clinics, Faculty of Veterinary Medicine, University of Pisa, Via Livornese Lato Monte, San Piero a Grado, 56122 Pisa, Italy
2Department of Animal Pathology, Faculty of Veterinary Medicine, University of Pisa, Delle Piagge 2 Avenue, 56100 Pisa, Italy
3Small Animal Teaching Hospital, University of Liverpool, Leahurst, Liverpool, Leahurst Campus Chester High Road, Neston, Wirral CH64 7TE, UK

Received 21 November 2011; Accepted 16 January 2012

Academic Editor: M. Bugno-Poniewierska

Copyright © 2012 Giovanni Barsotti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


An 8-year-old male pug with a 12-month history of a progressive nonpainful mass on the left cornea was evaluated. Ocular examination showed a severe bilateral keratoconjunctivitis sicca, pigmentary keratitis, and an exophytic irregular pink mass occupying approximately 75% of the total corneal surface of the left eye. A squamous cell carcinoma (SCC) was suspected on cytology, and clinical investigations showed no evidence of metastases. A transpalpebral enucleation was therefore performed, and the diagnosis of SCC was confirmed on histopathology. Immunohistochemical investigations showed that the neoplastic cells were pan-cytokeratin positive and vimentin negative. Additionally, nuclei immunoreactive to Ki-67 antigen were detected. Tumor cells were also negative to p53. Immunoreactivity to COX-2 was found in less than 10% of the neoplastic cells. No adjuvant therapies were instituted, and no evidence of local recurrence or distance metastasis was identified during the 24-month follow-up period.