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Case Reports in Veterinary Medicine
Volume 2013, Article ID 728167, 4 pages
http://dx.doi.org/10.1155/2013/728167
Case Report

Rapid Evaluation of Mutant Exon-11 in c-kit in a Recurrent MCT Case Using CD117 Immunocytofluorescence, FACS-Cell Sorting, and PCR

1STAR, Molecular Biology Research on Animal Oncology, Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand
2Biochemistry Unit, Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand
3Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10770, Thailand

Received 4 June 2013; Accepted 5 August 2013

Academic Editors: J. Lakritz, F. Mutinelli, and S. Stuen

Copyright © 2013 Dettachai Ketpun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. M. Welle, C. R. Bley, J. Howard, and S. Rüfenacht, “Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment,” Veterinary Dermatology, vol. 19, no. 6, pp. 321–339, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Morini, G. Bettini, R. Preziosi, and L. Mandrioli, “C-kit gene product (CD117) immunoreactivity in canine and feline paraffin sections,” Journal of Histochemistry and Cytochemistry, vol. 52, no. 5, pp. 705–708, 2004. View at Google Scholar · View at Scopus
  3. S. Letard, Y. Yang, K. Hanssens et al., “Gain-of-function mutations in the extracellular domain of KIT are common in canine mast cell tumors,” Molecular Cancer Research, vol. 6, no. 7, pp. 1137–1145, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. C. A. London, P. B. Malpas, S. L. Wood-Follis et al., “Multi-center, placebo-controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision,” Clinical Cancer Research, vol. 15, no. 11, pp. 3856–3865, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Kiupel, J. D. Webster, K. L. Bailey et al., “Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior,” Veterinary Pathology, vol. 48, no. 1, pp. 147–155, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. C. L. R. Jones, R. A. Grahn, M. B. Chien, L. A. Lyons, and C. A. London, “Detection of c-kit mutations in canine mast cell tumors using fluorescent polyacrylamide gel electrophoresis,” Journal of Veterinary Diagnostic Investigation, vol. 16, no. 2, pp. 95–100, 2004. View at Google Scholar · View at Scopus
  7. R. Zavodovskaya, M. B. Chien, and C. A. London, “Use of kit internal tandem duplications to establish mast cell tumor clonality in 2 dogs,” Journal of Veterinary Internal Medicine, vol. 6, pp. 915–917, 2004. View at Google Scholar
  8. J. D. Webster, V. Yuzbasiyan-Gurkan, J. B. Kaneene, R. Miller, J. H. Resau, and M. Kiupel, “The role of c-kit in tumorigenesis: evaluation in canine cutaneous mast cell tumors,” Neoplasia, vol. 8, no. 2, pp. 104–111, 2006. View at Publisher · View at Google Scholar · View at Scopus