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Case Reports in Veterinary Medicine
Volume 2013, Article ID 906782, 3 pages
Case Report

Rabies in Two Bison from Colorado

1National Wildlife Research Center, Animal and Plant Health Inspection Service, Veterinary Services, 4101 Laporte Avenue, Fort Collins, CO 80521, USA
2Veterinary Diagnostic Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523-1644, USA
3Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, 2005 Research Park Circle, Manhattan, KS 66502, USA
4Animal Reproduction and Biotechnology Laboratory, Colorado State University, 3100 Rampart Road, Fort Collins, CO 80523, USA
5Department of Clinical Sciences, College of Veterinary Medicine, Colorado State University, Fort Collins, CO 80523, USA

Received 28 March 2013; Accepted 17 April 2013

Academic Editors: L. G. Papazoglou and M. Woldemeskel

Copyright © 2013 Jack C. Rhyan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Two adult female bison, housed in an outdoor research facility and observed daily, died suddenly three days apart. Minimal coordination and behavioral changes were observed in one animal the evening before being found in a moribund state. Malignant catarrhal fever was suspected in both bison due to a recent confirmed MCF case with similar course. The cause of death was not apparent from necropsy, but brains of both animals were strongly positive for rabies virus antigen by fluorescent antibody and/or immunohistochemical tests. Minimal to mild encephalitis with Negri bodies was observed on histopathology. The bison were located in an area that had not been endemic for skunk rabies; however, a case of rabies in a skunk had been discovered 1.6 km north of the bison paddock two months prior to the bison cases.