Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Veterinary Medicine
Volume 2014, Article ID 640151, 6 pages
http://dx.doi.org/10.1155/2014/640151
Case Report

Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum Infection

Dipartimento di Scienze Veterinarie per la Salute, la Produzione Animale e la Sicurezza Alimentare, Università degli Studi di Milano, Via G. Celoria, 10-20133 Milano, Italy

Received 18 April 2014; Revised 7 July 2014; Accepted 23 July 2014; Published 14 August 2014

Academic Editor: Katerina K. Adamama-Moraitou

Copyright © 2014 Daniela Proverbio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Baneth, “Canine leishmaniasis: bridging science, public health and politics,” Veterinary Journal, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Baneth, A. F. Koutinas, L. Solano-Gallego, P. Bourdeau, and L. Ferrer, “Canine leishmaniosis—new concepts and insights on an expanding zoonosis: part one,” Trends in Parasitology, vol. 24, no. 7, pp. 324–330, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Ciaramella, G. Oliva, R. de Luna et al., “A retrospective clinical study of canine leishmaniasis in 150 dogs naturally infected by Leishmania infantum,” Veterinary Record, vol. 141, no. 21, pp. 539–543, 1997. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Oliva, X. Roura, A. Crotti et al., “Guidelines for treatment of leishmaniasis in dogs,” Journal of the American Veterinary Medical Association, vol. 236, no. 11, pp. 1192–1198, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Baneth and S. E. Shaw, “Chemotherapy of canine leishmaniosis,” Veterinary Parasitology, vol. 106, no. 4, pp. 315–324, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. E. Spada, D. Proverbio, D. Groppetti, R. Perego, V. Grieco, and E. Ferro, “First report of the use of meglumine antimoniate for treatment of canine leishmaniasis in a pregnant dog,” Journal of the American Animal Hospital Association, vol. 47, no. 1, pp. 67–71, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Noli and S. T. Auxilia, “Treatment of canine old world visceral leishmaniasis: a systematic review,” Veterinary Dermatology, vol. 16, no. 4, pp. 213–232, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Solano-Gallego, A. Koutinas, G. Miró et al., “Directions for the diagnosis, clinical staging, treatment and prevention of canine leishmaniosis,” Veterinary Parasitology, vol. 165, no. 1-2, pp. 1–18, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Miró, G. Oliva, I. Cruz et al., “Multicentric, controlled clinical study to evaluate effectiveness and safety of miltefosine and allopurinol for canine leishmaniosis,” Veterinary Dermatology, vol. 20, no. 5-6, pp. 397–404, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. V. Woerly, L. Maynard, A. Sanquer, and H. Eun, “Clinical efficacy and tolerance of miltefosine in the treatment of canine leishmaniosis,” Parasitology Research, vol. 105, no. 2, pp. 463–469, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. B. D. Pandey, K. Pandey, O. Kaneko, T. Yanagi, and K. Hirayama, “Short report: Relapse of visceral leishmaniasis after miltefosine treatment in a nepalese patient,” The American Journal of Tropical Medicine and Hygiene, vol. 80, no. 4, pp. 580–582, 2009. View at Google Scholar · View at Scopus
  12. M. Calvopina, E. A. Gomez, H. Sindermann, P. J. Cooper, and Y. Hashiguchi, “Relapse of new world diffuse cutaneous leishmaniasis caused by Leishmania (Leishmania) mexicana after miltefosine treatment,” American Journal of Tropical Medicine and Hygiene, vol. 75, no. 6, pp. 1074–1077, 2006. View at Google Scholar · View at Scopus
  13. V. N. R. Das, K. Pandey, N. Verma et al., “Short report: development of post-kala-azar dermal leishmaniasis (PKDL) in miltefosine-treated visceral leishmaniasis,” The American Journal of Tropical Medicine and Hygiene, vol. 80, no. 3, pp. 336–338, 2009. View at Google Scholar · View at Scopus
  14. L. Manna, F. Vitale, S. Reale et al., “Study of efficacy of miltefosine and allopurinol in dogs with leishmaniosis,” Veterinary Journal, vol. 182, no. 3, pp. 441–445, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Mateo, L. Maynard, C. Vischer, P. Bianciardi, and G. Miró, “Comparative study on the short term efficacy and adverse effects of miltefosine and meglumine antimoniate in dogs with natural leishmaniosis,” Parasitology Research, vol. 105, no. 1, pp. 155–162, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. H. M. Andrade, V. P. C. P. Toledo, M. B. Pinheiro et al., “Evaluation of miltefosine for the treatment of dogs naturally infected with L. infantum (=L. chagasi) in Brazil,” Veterinary Parasitology, vol. 181, no. 2-4, pp. 83–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Rijal, B. Ostyn, S. Uranw et al., “Increasing failure of miltefosine in the treatment of kala-azar in nepal and the potential role of parasite drug resistance, reinfection, or noncompliance,” Clinical Infectious Diseases, vol. 56, no. 11, pp. 1530–1538, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. T. P. Dorlo, S. Rijal, B. Ostyn et al., “Failure of miltefosine in visceral leishmaniasis is associated with low drug exposure,” Journal of Infectious Diseases, vol. 210, no. 1, pp. 146–153, 2014. View at Publisher · View at Google Scholar
  19. J. Soto, J. Rea, M. Valderrama et al., “Short report: efficacy of extended (six weeks) treatment with miltefosine for mucosal leishmaniasis in Bolivia,” American Journal of Tropical Medicine and Hygiene, vol. 81, no. 3, pp. 387–389, 2009. View at Google Scholar · View at Scopus
  20. H. C. Maltezou, “Drug resistance in visceral leishmaniasis,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 617521, 8 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Mishra, A. Saxena, and S. Singh, “Chemotherapy of leishmaniasis: past, present and future,” Current Medicinal Chemistry, vol. 14, no. 10, pp. 1153–1169, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Sundar and P. L. Olliaro, “Miltefosine in the treatment of leishmaniasis: clinical evidence for informed clinical risk management,” Therapeutics and Clinical Risk Management, vol. 3, no. 5, pp. 733–740, 2007. View at Google Scholar · View at Scopus
  23. S. Sundar and A. Singh, “What steps can be taken to counter the increasing failure of miltefosine to treat visceral leishmaniasis?” Expert Review of Anti-Infective Therapy, vol. 11, no. 2, pp. 117–119, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Maia, M. Nunes, M. Marques, S. Henriques, N. Rolão, and L. Campino, “In vitro drug susceptibility of Leishmania infantum isolated from humans and dogs,” Experimental Parasitology, vol. 135, no. 1, pp. 36–41, 2013. View at Publisher · View at Google Scholar · View at Scopus