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Case Reports in Veterinary Medicine
Volume 2018 (2018), Article ID 6160980, 6 pages
https://doi.org/10.1155/2018/6160980
Case Report

Hemangiosarcoma in a Dog: Unusual Presentation and Increased Survival Using a Complementary/Holistic Approach Combined with Metronomic Chemotherapy

1Chaikin Associates LLC, 8388 South Tamiami Trail, Sarasota, FL 34238, USA
2Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers University, New Brunswick, NJ, USA
3Blue Pearl Veterinary Partners, 7414 South Tamiami Trail, Sarasota, FL 34231, USA

Correspondence should be addressed to Philip Chaikin

Received 28 July 2017; Revised 2 November 2017; Accepted 8 November 2017; Published 5 February 2018

Academic Editor: Isabel Pires

Copyright © 2018 Philip Chaikin and Anja Welihozkiy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. C. Helfand, “Canine hemangiosarcoma: A tumor of contemporary interest,” Cancer Therapy, vol. 6, pp. 457–462, 2008. View at Google Scholar
  2. S. Lana, L. U'ren, S. Plaza et al., “Continuous low-dose oral chemotherapy for adjuvant therapy of splenic hemangiosarcoma in dogs,” Journal of Veterinary Internal Medicine, vol. 21, no. 4, pp. 764–769, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. D. C. Brown and J. Reetz, “Single agent polysaccharopeptide delays metastases and improves survival in naturally occurring hemangiosarcoma,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 384301, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. S. A. Kahn, C. M. Mullin, L.-P. De Lorimier et al., “Doxorubicin and deracoxib adjuvant therapy for canine splenic hemangiosarcoma: A pilot study,” Canadian Veterinary Journal, vol. 54, no. 3, pp. 237–242, 2013. View at Google Scholar · View at Scopus
  5. L. B. C. Treixeira and R. R. Dubiezig, Ocular metastasis in dogs: a retrospective study of 320 cases, Association for Research in Vision and Ophthalmology-ARVO, Seattle, WA, 2016.
  6. B. Biller, “Metronomic chemotherapy in veterinary patients with cancer: Rethinking the targets and strategies of chemotherapy,” Veterinary Clinics of North America - Small Animal Practice, vol. 44, no. 5, pp. 817–829, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. R. E. Elmslie, P. Glawe, and S. W. Dow, “Metronomic therapy with cyclophosphamide and piroxicam effectively delays tumor recurrence in dogs with incompletely resected soft tissue sarcomas,” Journal of Veterinary Internal Medicine, vol. 22, no. 6, pp. 1373–1379, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. K. K. Chu, S. S. S. Ho, and A. H. Chow, “Coriolus versicolor: a medicinal mushroom with promising immunotherapeutic values,” Journal of Clinical Pharmacology, vol. 42, no. 9, pp. 976–984, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. T.-C. Hsieh, P. Wu, S. Park, and J. M. Wu, “Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signalling regulatory protein expression by water extracts of I'm-Yunity™ (PSP),” BMC Complementary and Alternative Medicine, vol. 6, article no. 30, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. P. M. Kidel, “The use of mushroom glycans and proteoglycans in cancer treatment,” Alternative Medicine Review, vol. 5, no. 1, pp. 4–27, 2000. View at Google Scholar
  11. J. P. A. Nicandro, C. Tsourounis, L. Frassetto, and B. J. Guglielmo, “In vivo effect of I'm-Yunity™ on hepatic cytochrome P450 3A4,” Journal of Herbal Pharmacotherapy, vol. 7, no. 1, pp. 39–56, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. K. A. Wirth, K. Kow, M. E. Salute, N. J. Bacon, and R. J. Milner, “In vitro effects of Yunnan Baiyao on canine hemangiosarcoma cell lines,” Veterinary and Comparative Oncology, vol. 14, no. 3, pp. 281–294, 2016. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Kim, A. Graef, E. Dickerson, and J. Modiano, “Pathobiology of Hemangiosarcoma in Dogs: Research Advances and Future Perspectives,” Veterinary Sciences, vol. 2, no. 4, pp. 388–405, 2015. View at Publisher · View at Google Scholar
  14. National Cancer Institute: Cancer researchers report progress in studying exceptional responders, National Cancer Institute, Cancer researchers report progress in studying exceptional responders, 2017, https://www.cancer.gov/news-events/cancer-currents-blog/2017/exceptional-responders-progress.