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Case Reports in Veterinary Medicine
Volume 2018, Article ID 9078537, 6 pages
Case Report

Injectable Chemotherapy Downstaged Oral Squamous Cell Carcinoma from Nonresectable to Resectable in a Rescue Dog: Diagnosis, Treatment, and Outcome

1HylaPharm LLC, 2029 Becker Drive, Lawrence, KS 66047, USA
2University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA
3State Line Animal Hospital, Leawood, KS 66206, USA
4University of Kansas, 2095 Constant Ave., Lawrence, KS 66047, USA

Correspondence should be addressed to Marcus Laird Forrest;

Received 2 May 2018; Accepted 13 September 2018; Published 8 October 2018

Academic Editor: Sheila C. Rahal

Copyright © 2018 Shuang Cai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This case report documents the diagnosis, treatment, and outcome of a nonresectable oral squamous cell carcinoma in a dog with initial poor prognosis. An approximately 4-year-old female Staffordshire Bull Terrier presented with a large mass on the front of lower jaw which was diagnosed as oral papillary squamous cell carcinoma by histopathology. CT scans revealed invasion of the cancer to the frenulum of the tongue. The mass was inoperable due to location, expansiveness, and metastatic lymph nodes. The dog received 4 treatments of intralesional hyaluronan-platinum conjugates (HylaPlat™, HylaPharm LLC, Lawrence, Kansas) at 3-week intervals. Clinical chemistry and complete blood count were performed one week after each treatment and results were within normal limits. Complications included bleeding due to tumor tissue sloughing, as well as a single seizure due to unknown causes. Upon completion of chemotherapy, CT showed that the mass had regressed and was no longer invading the lingual frenulum, and multiple lymph nodes were free of metastasis. The mass thus became resectable and the dog successfully underwent rostral bilateral mandibulectomy. Over one year after chemotherapy and surgery, the cancer remains in complete remission.