Effect of Pravastatin as an Adjunctive Therapeutic for Mitral Insufficiency with Hyperlipidemia in a Dog

Table 2

Echocardiographic and circulation variables after pravastatin administration.

Variables	Time (days)
	0	11	30	45	65	96	121	150	211	283	375
Body weight (kg)	4.3	4.4	4.3	4.3	4.3	4.2	4.2	4.2	4.2	4.2	4.2
Radiographic vertebrae heart size (VHS)	11.0	10.5	10.3	10.5	10.3	10.0	10.0	10.5	10.0	9.8	10.5
Heart rate (beats/min)	150	139	132	107	132	130	119	110	101	114	131
Systolic blood pressure (SBP; mmHg)	126	168	154	148	148	160	178	164	156	153	154
Diastolic blood pressure (DBP; mmHg)	68	83	91	73	90	105	99	107	100	93	84
Mean blood pressure (MAP; mmHg)	87	100	109	100	105	135	120	135	121	122	104
Left atrium (LA; mm)	19.5	15.9	16.3	16.4	16.2	17.2	16.9	16.2	16.2	13.3	14.1
Right atrium (RA; mm)	13	12.3	12.3	12.5	11.5	11.9	13	11	13	10.2	11.4
Aorta (Ao; mm)	11.2	11.1	11.5	11.7	12.1	12.6	12.4	12.6	12.5	11.3	12.4
LA/Ao	1.74	1.43	1.42	1.40	1.34	1.37	1.36	1.29	1.29	1.18	1.14
RA/Ao	1.16	1.11	1.06	1.06	0.95	0.94	1.04	0.87	1.04	0.9	0.91
LV fractional shortening (FS; %)	57	43	52	47	47	51	43	47	45	43	43
LV ejection fraction (EF; %)	88	76	84	80	80	84	75	80	78	76	76
End-systolic left ventricular inner dimension (LVIDs; mm)	12.7	16.4	13	15.1	14	13.2	15.8	14.9	15.7	16.6	17
End-diastolic left ventricular inner dimension (LVIDd; mm)	29.6	28.7	26.8	28.7	26.3	26.8	27.4	28.1	29.6	29.4	30.1
Normalized end-diastolic left ventricular inner dimension (LVIDdN)	1.90	1.85	1.74	1.86	1.71	1.75	1.84	1.84	1.94	1.92	1.97
Pulmonary valve flow velocity (m/s)	0.78	0.78	1.00	0.89	1.09	1.01	0.89	1.03	0.80	0.82	0.89
Peak velocity of early diastolic transmitral flow wave (; cm/s)	76.5	97.0	78.0	93.6	75.2	84.0	72.0	91.9	83.1	90.6	84.1
Peak velocity of late transmitral flow wave (; cm/s)	94.3	70.2	62.3	66.3	71.1	58.7	61.5	61.7	69.6	60.4	65.7
	0.81	1.38	1.25	1.41	1.06	1.43	1.17	1.49	1.19	1.5	1.28
Deceleration time of early diastolic transmitral flow (DTE; ms)	108	80	104	108	136	136	104	92	104	120	120
Stroke volume (SV; mL)	5.1	5.2	3.8	3.6	5.0	7.2	4.7	4.3	4.9	6.1	6.1
Aortic ejection flow velocity (AEV; m/s)	0.73	0.86	0.99	0.88	0.83	0.91	0.76	0.84	1.26	0.80	0.84
Cardiac output (CO; L/min)	0.668	0.680	0.381	0.339	0.544	0.694	0.484	0.633	0.494	0.522	0.497
Peak velocity of aortic valve regurgitation (AR; cm/s)	129	216	104	275	245	214	147	256	241	260	265
Maximum systolic mitral regurgitation velocity (MRmax; m/s)	5.76	6.10	5.98	5.86	5.32	5.63	5.40	5.64	5.70	5.25	5.54
Maximum tricuspid regurgitation velocity (TRmax; m/s)	3.20	2.97	2.17	2.73	2.88	2.83	2.63	2.67	2.67	2.60	2.23
Systolic pulmonary arterial pressure (sPA; mmHg)	51.0	45.3	28.8	39.8	43.2	42.0	37.7	38.5	38.5	37.0	29.9
Left ventricular Tei index	0.49	0.49	0.55	0.38	0.32	0.77	0.70	0.51	0.29	0.53	0.40
Right ventricular Tei index	0.13	0.30	0.18	0.22	0.37	0.40	0.23	0.33	0.30	0.66	0.55
Peak velocity of early diastolic mitral annular motion (Em; cm/s)	6.7	8.4	6.5	10.2	9.1	6.7	6.5	7.1	4.9	5.8	7.4
Peak velocity of diastolic mitral annular motion (Am; cm/s)	11.5	13.1	7.7	11.6	10.8	9.6	9.2	8.5	7.4	9.7	11
Em/Am	0.58	0.64	0.84	0.88	0.84	0.70	0.70	0.83	0.65	0.60	0.67
E/Em	11.5	11.5	12.1	9.2	8.2	12.6	11.0	12.9	16.9	16.1	9.5
Tricuspid annular plane systolic excursion (TAPSE; mm)	12.1	13.0	12.4	13.2	11.4	12.5	11.9	11.9	11.7	11.0	10.2