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Variables | Time (days) |
0 | 11 | 30 | 45 | 65 | 96 | 121 | 150 | 211 | 283 | 375 |
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Body weight (kg) | 4.3 | 4.4 | 4.3 | 4.3 | 4.3 | 4.2 | 4.2 | 4.2 | 4.2 | 4.2 | 4.2 |
Radiographic vertebrae heart size (VHS) | 11.0 | 10.5 | 10.3 | 10.5 | 10.3 | 10.0 | 10.0 | 10.5 | 10.0 | 9.8 | 10.5 |
Heart rate (beats/min) | 150 | 139 | 132 | 107 | 132 | 130 | 119 | 110 | 101 | 114 | 131 |
Systolic blood pressure (SBP; mmHg) | 126 | 168 | 154 | 148 | 148 | 160 | 178 | 164 | 156 | 153 | 154 |
Diastolic blood pressure (DBP; mmHg) | 68 | 83 | 91 | 73 | 90 | 105 | 99 | 107 | 100 | 93 | 84 |
Mean blood pressure (MAP; mmHg) | 87 | 100 | 109 | 100 | 105 | 135 | 120 | 135 | 121 | 122 | 104 |
Left atrium (LA; mm) | 19.5 | 15.9 | 16.3 | 16.4 | 16.2 | 17.2 | 16.9 | 16.2 | 16.2 | 13.3 | 14.1 |
Right atrium (RA; mm) | 13 | 12.3 | 12.3 | 12.5 | 11.5 | 11.9 | 13 | 11 | 13 | 10.2 | 11.4 |
Aorta (Ao; mm) | 11.2 | 11.1 | 11.5 | 11.7 | 12.1 | 12.6 | 12.4 | 12.6 | 12.5 | 11.3 | 12.4 |
LA/Ao | 1.74 | 1.43 | 1.42 | 1.40 | 1.34 | 1.37 | 1.36 | 1.29 | 1.29 | 1.18 | 1.14 |
RA/Ao | 1.16 | 1.11 | 1.06 | 1.06 | 0.95 | 0.94 | 1.04 | 0.87 | 1.04 | 0.9 | 0.91 |
LV fractional shortening (FS; %) | 57 | 43 | 52 | 47 | 47 | 51 | 43 | 47 | 45 | 43 | 43 |
LV ejection fraction (EF; %) | 88 | 76 | 84 | 80 | 80 | 84 | 75 | 80 | 78 | 76 | 76 |
End-systolic left ventricular inner dimension (LVIDs; mm) | 12.7 | 16.4 | 13 | 15.1 | 14 | 13.2 | 15.8 | 14.9 | 15.7 | 16.6 | 17 |
End-diastolic left ventricular inner dimension (LVIDd; mm) | 29.6 | 28.7 | 26.8 | 28.7 | 26.3 | 26.8 | 27.4 | 28.1 | 29.6 | 29.4 | 30.1 |
Normalized end-diastolic left ventricular inner dimension (LVIDdN) | 1.90 | 1.85 | 1.74 | 1.86 | 1.71 | 1.75 | 1.84 | 1.84 | 1.94 | 1.92 | 1.97 |
Pulmonary valve flow velocity (m/s) | 0.78 | 0.78 | 1.00 | 0.89 | 1.09 | 1.01 | 0.89 | 1.03 | 0.80 | 0.82 | 0.89 |
Peak velocity of early diastolic transmitral flow wave (; cm/s) | 76.5 | 97.0 | 78.0 | 93.6 | 75.2 | 84.0 | 72.0 | 91.9 | 83.1 | 90.6 | 84.1 |
Peak velocity of late transmitral flow wave (; cm/s) | 94.3 | 70.2 | 62.3 | 66.3 | 71.1 | 58.7 | 61.5 | 61.7 | 69.6 | 60.4 | 65.7 |
| 0.81 | 1.38 | 1.25 | 1.41 | 1.06 | 1.43 | 1.17 | 1.49 | 1.19 | 1.5 | 1.28 |
Deceleration time of early diastolic transmitral flow (DTE; ms) | 108 | 80 | 104 | 108 | 136 | 136 | 104 | 92 | 104 | 120 | 120 |
Stroke volume (SV; mL) | 5.1 | 5.2 | 3.8 | 3.6 | 5.0 | 7.2 | 4.7 | 4.3 | 4.9 | 6.1 | 6.1 |
Aortic ejection flow velocity (AEV; m/s) | 0.73 | 0.86 | 0.99 | 0.88 | 0.83 | 0.91 | 0.76 | 0.84 | 1.26 | 0.80 | 0.84 |
Cardiac output (CO; L/min) | 0.668 | 0.680 | 0.381 | 0.339 | 0.544 | 0.694 | 0.484 | 0.633 | 0.494 | 0.522 | 0.497 |
Peak velocity of aortic valve regurgitation (AR; cm/s) | 129 | 216 | 104 | 275 | 245 | 214 | 147 | 256 | 241 | 260 | 265 |
Maximum systolic mitral regurgitation velocity (MRmax; m/s) | 5.76 | 6.10 | 5.98 | 5.86 | 5.32 | 5.63 | 5.40 | 5.64 | 5.70 | 5.25 | 5.54 |
Maximum tricuspid regurgitation velocity (TRmax; m/s) | 3.20 | 2.97 | 2.17 | 2.73 | 2.88 | 2.83 | 2.63 | 2.67 | 2.67 | 2.60 | 2.23 |
Systolic pulmonary arterial pressure (sPA; mmHg) | 51.0 | 45.3 | 28.8 | 39.8 | 43.2 | 42.0 | 37.7 | 38.5 | 38.5 | 37.0 | 29.9 |
Left ventricular Tei index | 0.49 | 0.49 | 0.55 | 0.38 | 0.32 | 0.77 | 0.70 | 0.51 | 0.29 | 0.53 | 0.40 |
Right ventricular Tei index | 0.13 | 0.30 | 0.18 | 0.22 | 0.37 | 0.40 | 0.23 | 0.33 | 0.30 | 0.66 | 0.55 |
Peak velocity of early diastolic mitral annular motion (Em; cm/s) | 6.7 | 8.4 | 6.5 | 10.2 | 9.1 | 6.7 | 6.5 | 7.1 | 4.9 | 5.8 | 7.4 |
Peak velocity of diastolic mitral annular motion (Am; cm/s) | 11.5 | 13.1 | 7.7 | 11.6 | 10.8 | 9.6 | 9.2 | 8.5 | 7.4 | 9.7 | 11 |
Em/Am | 0.58 | 0.64 | 0.84 | 0.88 | 0.84 | 0.70 | 0.70 | 0.83 | 0.65 | 0.60 | 0.67 |
E/Em | 11.5 | 11.5 | 12.1 | 9.2 | 8.2 | 12.6 | 11.0 | 12.9 | 16.9 | 16.1 | 9.5 |
Tricuspid annular plane systolic excursion (TAPSE; mm) | 12.1 | 13.0 | 12.4 | 13.2 | 11.4 | 12.5 | 11.9 | 11.9 | 11.7 | 11.0 | 10.2 |
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