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Canadian Respiratory Journal
Volume 2, Suppl A, Pages 24A-31A
http://dx.doi.org/10.1155/1995/956715
Treatment of Asthma: From the Child to the Adult

Nonsteroidal Anti-Inflammatory Agents in the Treatment of Asthma in Children

Pierre Gaudreault

Department of Pediatrics, University of Montreal, and Clinical Pharmacology and Toxicology Section and Emergency Medicine Service, Hôpital Sainte-Justine, Montréal, Québec, Canada

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The increasing scientific information clearly demonstrates the important role of inflammation in asthma. This evidence has led physicians to focus their treatment on the elimination of inflammation instead of working solely against bronchoconstriction. Steroids and nonsteroidal agents are currently used to prevent this inflammatory component. This paper focuses only on nonstcroidal anti-inflammatory agents such as sodium cromoglycate, nedocromil sodium and ketotifen and their use in pediatric asthma. The discussion on each medication addresses its mechanism of action, the evidence concerning its efficacy in pediatrics (ie, clinical pharmacology, acute bronchial challenge, late asthmatic response, bronchial hyperrcactivity, clinical efficacy) and the pediatric dose.